Application Data
alpha-Synuclein Recombinant Protein | Snca recombinant protein
alpha-Synuclein Protein, Mouse, Recombinant (His Tag), HPLC-verified
Gene Names
Snca; NACP; alphaSYN
Purity
>= 95% as determined by SDS-PAGE.= 95% as determined by SEC-HPLC.
Synonyms
alpha-Synuclein; N/A; alpha-Synuclein Protein, Mouse, Recombinant (His Tag), HPLC-verified; synuclein, alpha (non A4 component of amyloid precursor); alphaSYN Protein, Mouse; NACP Protein, Mouse; Snca recombinant protein
Host
E coli
Purity/Purification
>= 95% as determined by SDS-PAGE.
= 95% as determined by SEC-HPLC.
= 95% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Species
Mouse
Predicted N Terminal
Met
Endotoxin
<1.0 EU per ug protein as determined by the LAL method.
Protein Construction
A DNA sequence encoding the Mouse SNCA (O55042-1)(Met1-Ala140) was expressed with a polyhistidine tag at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for Snca recombinant protein
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). Besides, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.
References
Arima K, et al. (1998) Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes onthe filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. Brain Res. 808 (1): 93-100.
Arima K, et al. (1998) NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy.
Acta Neuropathol. 96 (5): 439-44.Lee HJ, et al. (2001) Membrane-bound alpha-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form. The Journal of Biological Chemistry. 277: 671-8.
Arima K, et al. (1998) NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy.
Acta Neuropathol. 96 (5): 439-44.Lee HJ, et al. (2001) Membrane-bound alpha-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form. The Journal of Biological Chemistry. 277: 671-8.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,485 Da
NCBI Official Full Name
alpha-synuclein
NCBI Official Synonym Full Names
synuclein, alpha
NCBI Official Symbol
Snca
NCBI Official Synonym Symbols
NACP; alphaSYN
NCBI Protein Information
alpha-synuclein; alpha SYN; non-A4 component of amyloid; non-A beta component of AD amyloid
UniProt Protein Name
Alpha-synuclein
UniProt Gene Name
Snca
UniProt Synonym Gene Names
Syn; NACP
UniProt Entry Name
SYUA_MOUSE
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Product Notes
The Snca snca (Catalog #AAA259266) is a Recombinant Protein produced from E coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "alpha-Synuclein, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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