Application Data
(PrimaryrathippocampalneuronstreatedwithhumanbetasynucleinPre-formedFibrils(AAA254089)donotshowLewybodyinclusionformation.Fibrilsweresonicated1hourandaddedat1ug/mLconcentration.A)Hoechst.B)pSer129.C)Merge.)
Beta Synuclein (Type 1) Recombinant Protein | SNCB recombinant protein
Human Recombinant Beta Synuclein Protein Pre-formed Fibrils (Type 1)
Applications
SDS-Page, Western Blot
Purity
>95%; Ion-exchange Purified
Synonyms
Beta Synuclein (Type 1); N/A; Human Recombinant Beta Synuclein Protein Pre-formed Fibrils (Type 1); Beta Synuclein Pre-formed Fibrils (Type 1); Beta Synuclein; 14 kDa brain-specific protein aggregates; Beta-synuclein Protein Aggregates; Phosphoneuroprotein 14 Protein Aggregates; PNP14 Protein Aggregates; Sncb Protein Aggregates; Synuclein beta Protein Aggregates; SYUB_HUMAN Protein Aggregates; SNCB recombinant protein
Host
E coli
Purity/Purification
>95%; Ion-exchange Purified
Form/Format
PBS pH 7.4
Concentration
Lot/batch specific. See included datasheet. (varies by lot)
Sequence Length
Full length
Applicable Applications for SNCB recombinant protein
Invitro Assay, SDS-PAGE, WB (Western Blot)
Species
Human
Conjugation
No tag
Research Area
Neuroscience, Neurodegeneration, Alzheimer's Disease, Tangles & Tau, Neuroscience, Neurodegeneration, Parkinson's Disease, Synuclein
Cellular Localization
Cytoplasm
Certificate of Analysis
Certified >95% pure using SDS-PAGE analysis.
Other Relevant Information
For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information.
Preparation and Storage
Store at -80 degree C
Application Data
(PrimaryrathippocampalneuronstreatedwithhumanbetasynucleinPre-formedFibrils(AAA254089)donotshowLewybodyinclusionformation.Fibrilsweresonicated1hourandaddedat1ug/mLconcentration.A)Hoechst.B)pSer129.C)Merge.)
Application Data
(PrimaryrathippocampalneuronstreatedwithhumanbetasynucleinPre-formedFibrils(AAA254089)donotshowLewybodyinclusionformation.Fibrilsweresonicated1hourandaddedat1ug/mLconcentration.A)Hoechst.B)pSer129.C)Merge.)
Application Data
(TEMofActiveHumanRecombinantBetaSynucleinProteinPre-formedFibrils(Type1)(AAA254089))
Application Data
(TEMofActiveHumanRecombinantBetaSynucleinProteinPre-formedFibrils(Type1)(AAA254089))
Related Product Information for SNCB recombinant protein
Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Beta synuclein is abundant in neurofibrillary lesions of patients with Alzheimer's Disease. Beta synuclein is suggested to be an inhibitor of alpha synuclein aggregation- protecting the central nervous system from the neurotoxin effects of alpha synuclein (3).
Product Categories/Family for SNCB recombinant protein
References
1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146-148 (1907). 3. Taschenberger G., et al. (2013) Ann Neurol. 74(1): 109-118.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,288 Da
NCBI Official Full Name
beta-synuclein
NCBI Official Synonym Full Names
synuclein, beta
NCBI Official Symbol
SNCB
NCBI Protein Information
beta-synuclein
UniProt Protein Name
Beta-synuclein
UniProt Gene Name
SNCB
UniProt Entry Name
SYUB_HUMAN
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Product Notes
The SNCB sncb (Catalog #AAA254089) is a Recombinant Protein produced from E coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Beta Synuclein (Type 1) can be used in a range of immunoassay formats including, but not limited to, Invitro Assay, SDS-PAGE, WB (Western Blot). Researchers should empirically determine the suitability of the SNCB sncb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Beta Synuclein (Type 1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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