BCMA (CD269) Recombinant Protein | BCMA recombinant protein
Human BCMA (CD269) Recombinant
Purity
>95%, as determined by SDS-PAGE and HPLC
Synonyms
BCMA (CD269); N/A; Human BCMA (CD269) Recombinant; cd269; bcma; TNFRSF17; BCMA recombinant protein
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Form/Format
Recombinant BCMA was lyophilized from a 0.2 um filtered 30% acetonitrile, 0.1% TFA solution pH 7.5.
Host Note
Optimized DNA sequence encoding Human BCMA extracellular domain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Recombinant BCMA is a disulfide-linked monomer protein consisting of 54 amino acid residue subunits, and migrates as an approximately 6kDa protein under non-reducing and reducing conditions in SDS-PAGE.
Biological Activity
The ED(50) was not determined.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this product can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
Upon reconstitution, this product can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
Related Product Information for BCMA recombinant protein
BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes.The N-terminal part of both mouse and human proteins contains a conserved six- cysteine motif. BLyS binds to three receptors of the TNF receptor family (B cell maturation antigen BCMA, TACI, and BAFF-R), all of which are expressed by mature B cells.
Product Categories/Family for BCMA recombinant protein
References
• autoantibody-producing rp105– b cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with baff-r than normal subjects .Rheumatology, Jan 2010; 10.1093/rheumatology/kep437.
• adipocytes as immune cells: differential expression of tweak, baff, and april and their receptors (fn14, baff-r, taci, and BCMA) at different stages of normal and pathological adipose tissue development .J. Immunol., Nov 2009; 183: 5948 - 5956.
• activation of b-cell maturation antigen (BCMA) on human multiple myeloma cells by a proliferation-inducing ligand (april) promotes myeloma cell function in the bone marrow microenvironment. .Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 1503.
• the rgel/blys fusion toxin specifically targets malignant b cells expressing the blys receptors baff-r, taci, and BCMA .Mol. Cancer Ther., Feb 2007; 6: 460 - 470.
• hodgkin lymphoma cells express taci and BCMA receptors and generate survival and proliferation signals in response to baff and april .Blood, Jan 2007; 109: 729 - 739.
• adipocytes as immune cells: differential expression of tweak, baff, and april and their receptors (fn14, baff-r, taci, and BCMA) at different stages of normal and pathological adipose tissue development .J. Immunol., Nov 2009; 183: 5948 - 5956.
• activation of b-cell maturation antigen (BCMA) on human multiple myeloma cells by a proliferation-inducing ligand (april) promotes myeloma cell function in the bone marrow microenvironment. .Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 1503.
• the rgel/blys fusion toxin specifically targets malignant b cells expressing the blys receptors baff-r, taci, and BCMA .Mol. Cancer Ther., Feb 2007; 6: 460 - 470.
• hodgkin lymphoma cells express taci and BCMA receptors and generate survival and proliferation signals in response to baff and april .Blood, Jan 2007; 109: 729 - 739.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,165 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 17
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Gene Name
TNFRSF17
UniProt Synonym Gene Names
BCM; BCMA
UniProt Entry Name
TNR17_HUMAN
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Product Notes
The BCMA tnfrsf17 (Catalog #AAA76089) is a Recombinant Protein produced from E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders) and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BCMA (CD269), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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