OX40L/TNFSF4 Recombinant Protein | TNFSF4 recombinant protein

OX40L/TNFSF4 Protein, Mouse, Recombinant (ECD, His Tag)

Cat. Num. AAA257492

• Gene Names: Tnfsf4; Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l
• Purity: >95 % as determined by SDS-PAGE.
• Synonyms: OX40L/TNFSF4; N/A; OX40L/TNFSF4 Protein, Mouse, Recombinant (ECD, His Tag); Mouse OX40L/TNFSF4 Protein (ECD, His Tag); tumor necrosis factor (ligand) superfamily, member 4; Ath-1 Protein, Mouse; Ath1 Protein, Mouse; CD134L Protein, Mouse; gp34 Protein, Mouse; OX-40L Protein, Mouse; Ox40l Protein, Mouse; TXGP1 Protein, Mouse; Txgp1l Protein, Mouse; TNFSF4 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence Positions: 159aa
• Sequence: Ser51-Leu198

• Species: Mouse
• Tag: C-His
• Endotoxin: <1.0EU per ug protein as determined by the LAL method
• Predicted N Terminal: Ser51
• Protein Construction: |A DNA sequence encoding the mouse TNFSF4 (NP_033478.1) (Ser51-Leu198) was expressed with a polyhistidine tag at the C-terminus
• Activity: Measured by its binding ability in a functional ELISA. Immobilized TNFSF4 Protein, Mouse, (ECD, His Tag) (53582-M08H1) at 2ug/mL (100uL/well) can bind OX40, Human, (His & hFc Tag) (10481-H03H). The EC50 of OX40-Fc2h is 30-90ng/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; Shipping: They are shipped out with blue ice pack

Application Data

(Measured by its binding ability in a functional ELISA. Immobilized TNFSF4 Protein, Mouse, (ECD, His Tag) (53582-M08H1) at 2 ug/mL (100 uL/well) can bind OX40, Human, (His & hFc Tag)(10481-H03H), the EC50 of OX40-Fc2h is 30-90 ng/mL.)

Application Data

Related Product Information for TNFSF4 recombinant protein

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig-and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Product Categories/Family for TNFSF4 recombinant protein

Cancer Drug Targets

References

Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4. Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4. Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.

NCBI and Uniprot Product Information

• NCBI GI #: 6678473
• NCBI GeneID: 22164
• NCBI Accession #: NP_033478.1
• NCBI GenBank Nucleotide #: NM_009452.2
• UniProt Accession #: P43488
• Molecular Weight: 22,255 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 4
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 4
• NCBI Official Symbol: Tnfsf4
• NCBI Official Synonym Symbols: Ath1; gp34; Ath-1; Ox40l; TXGP1; CD134L; OX-40L; Txgp1l
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 4; OX40 ligand; atherosclerosis 1; tax-transcriptionally activated glycoprotein 1 ligand
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 4
• UniProt Gene Name: Tnfsf4
• UniProt Synonym Gene Names: Ox40l; Txgp1l; OX40L
• UniProt Entry Name: TNFL4_MOUSE