Application Data
TRIM21 recombinant protein
TRIM21 protein (His tag)
Gene Names
Trim21; Ro52; Ssa1
Purity
> 90% pure Purified using propietary chromatographic techniques.
Synonyms
TRIM21; N/A; TRIM21 protein (His tag); 52 KDa Ribonucleoprotein Autoantigen Ro; Ro-52 protein; Trim21 protein; RNF81 protein; RO52 protein; SSA protein; SSA1 protein; TRIM 21 protein; TRIM21 recombinant protein
Host
E.coli
Purity/Purification
> 90% pure
Purified using propietary chromatographic techniques.
Purified using propietary chromatographic techniques.
Form/Format
Liquid in 50mM Tris, pH 8.5, with 150mM NaCl, 0.02% SDS, 10% glycerol, 1mM EDTA, and 2mM DTT.
Concentration
1mg/ml (varies by lot)
Purification Method
Purified using proprietary chromatographic techniques
Protein Type
Recombinant
Biological Significance
TRIM21 is an intracellular antibody effector in the intracellular antibody-mediated proteolysis pathway. It binds to immunoglobulin G as well as immunoglobulin M on antibody marked non-enveloped virions which have infected the cell.
Species
Human
Residues
1-285aa
Tag/Conjugate
His tag
Expression
As a component of the proteolysis pathway, TRIM21 is expressed in most human tissues. Tissue and cell localizatin: TRIM21 is mainly found in the cytoplasm and the nucleus. Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.
Implications in Disease
TRIM21 interacts with autoantigens in patients with Sjogren's Syndrome and systematic lupus erythematosus.
Post-Translational Modifications
TRIM21 is autoubiquitinated which does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization. Ubiquitination occurs at Lys260.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Shipping: Ships on dry ice.
Upon receipt store at -70°C.
Avoid repeated freeze-thaw cycles.
Upon receipt store at -70°C.
Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Related Product Information for TRIM21 recombinant protein
Purified recombinant TRIM21 (Ro52) protein (His tag)
Product Categories/Family for TRIM21 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
31 kDa
NCBI Official Full Name
Trim21
NCBI Official Synonym Full Names
tripartite motif-containing 21
NCBI Official Symbol
Trim21
NCBI Official Synonym Symbols
Ro52; Ssa1
NCBI Protein Information
E3 ubiquitin-protein ligase TRIM21
UniProt Protein Name
Trim21 protein
UniProt Gene Name
Trim21
UniProt Entry Name
Q921V6_MOUSE
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Product Notes
The TRIM21 trim21 (Catalog #AAA24007) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TRIM21, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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