SDS-PAGE
Ubiquitin-protein ligase E3A Recombinant Protein | Ube3a recombinant protein
Recombinant Mouse Ubiquitin-protein ligase E3A
Gene Names
Ube3a; Hpve6a; mKIAA4216; 4732496B02; 5830462N02Rik; A130086L21Rik
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Ubiquitin-protein ligase E3A; N/A; Recombinant Mouse Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Ube3a recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
542-870aa; Partial
Sequence
HIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKLFWFNPSSFETEGQFTLIGILGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVISYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLLFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLNV
Sequence Length
870
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for Ube3a recombinant protein
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
Product Categories/Family for Ube3a recombinant protein
References
"Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases." Hatakeyama S., Jensen J.P., Weissman A.M. J. Biol. Chem. 272:15085-15092(1997)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39.9 kDa
NCBI Official Full Name
ubiquitin-protein ligase E3A isoform 2
NCBI Official Synonym Full Names
ubiquitin protein ligase E3A
NCBI Official Symbol
Ube3a
NCBI Official Synonym Symbols
Hpve6a; mKIAA4216; 4732496B02; 5830462N02Rik; A130086L21Rik
NCBI Protein Information
ubiquitin-protein ligase E3A
UniProt Protein Name
Ubiquitin-protein ligase E3A
UniProt Gene Name
Ube3a
UniProt Entry Name
UBE3A_MOUSE
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Product Notes
The Ube3a ube3a (Catalog #AAA115623) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 542-870aa; Partial. The amino acid sequence is listed below: HIIDDALVRL EMIAMENPAD LKKQLYVEFE GEQGVDEGGV SKEFFQLVVE EIFNPDIGMF TYDEATKLFW FNPSSFETEG QFTLIGILGL AIYNNCILDV HFPMVVYRKL MGKKGTFRDL GDSHPVLYQS LKDLLEYEGS VEDDMMITFQ ISQTDLFGNP MMYDLKENGD KIPITNENRK EFVISYSDYI LNKSVEKQFK AFRRGFHMVT NESPLKYLFR PEEIELLICG SRNLDFQALE ETTEYDGGYT RESVVIREFW EIVHSFTDEQ KRLFLLFTTG TDRAPVGGLG KLKMIIAKNG PDTERLPTSH TCFNVLLLPE YSSKEKLNV. It is sometimes possible for the material contained within the vial of "Ubiquitin-protein ligase E3A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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