SDS-PAGE
(The purity of LOXL1 was determined to be >70% by densitometry. Approx. MW 61 kDa.)
LOXL1 recombinant protein
LOXL1 recombinant protein
Gene Names
LOXL1; LOL; LOXL
Applications
Western Blot
Purity
>70%
Synonyms
LOXL1; LOXL1 recombinant protein; LOL; LOXL; LOXL1 Protein
Host
Sf9 insect cells
Purity/Purification
>70%
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 100mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.1ug/ul (varies by lot)
Sequence Length
2346
Applicable Applications for LOXL1 recombinant protein
Western Blot (WB)
Type
Recombinant Fusion Protein
Species
Human
Tag Information
GST tag
Expression System
Sf9 insect cells using baculovirus
Source Note
Recombinant human LOXL1 (292-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Gene Accession Number
BC015090
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: ships with Dry Ice
Shipping: ships with Dry Ice
SDS-PAGE
(The purity of LOXL1 was determined to be >70% by densitometry. Approx. MW 61 kDa.)
SDS-PAGE
(The purity of LOXL1 was determined to be >70% by densitometry. Approx. MW 61 kDa.)
Related Product Information for LOXL1 recombinant protein
Recombinant human LOXL1 (292-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: LOXL1 is a member of the lysyl oxidase gene family which is essential to the biogenesis of connective tissue. LOXL1 encodes an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. LOXL1 is responsible for catalyzing the oxidative deamination of lysine residues of tropoelastin and this deamination causes spontaneous cross-linking and formation of elastin polymer fibers (1). LOXL1 serves both as a crosslinking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin (2).
Scientific Background: LOXL1 is a member of the lysyl oxidase gene family which is essential to the biogenesis of connective tissue. LOXL1 encodes an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. LOXL1 is responsible for catalyzing the oxidative deamination of lysine residues of tropoelastin and this deamination causes spontaneous cross-linking and formation of elastin polymer fibers (1). LOXL1 serves both as a crosslinking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin (2).
Product Categories/Family for LOXL1 recombinant protein
References
1. Hewitt, A. W.et.al: Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people. Hum. Molec. Genet. 17: 710-716, 2008.
2. Liu, X. et.al: Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nature Genet. 36: 178-182, 2004.
2. Liu, X. et.al: Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nature Genet. 36: 178-182, 2004.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
~61 kDa
NCBI Official Full Name
Homo sapiens lysyl oxidase-like 1, mRNA
NCBI Official Synonym Full Names
lysyl oxidase-like 1
NCBI Official Symbol
LOXL1
NCBI Official Synonym Symbols
LOL; LOXL
NCBI Protein Information
lysyl oxidase homolog 1; lysyl oxidase-like protein 1
UniProt Protein Name
Lysyl oxidase homolog 1
UniProt Gene Name
LOXL1
UniProt Synonym Gene Names
LOXL; LOL
UniProt Entry Name
LOXL1_HUMAN
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Product Notes
The LOXL1 loxl1 (Catalog #AAA14246) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is GST tag!!Expression System||Sf9 insect cells using baculovirus!!Source Note||Recombinant human LOXL1 (292-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. AAA Biotech's LOXL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LOXL1 loxl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LOXL1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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