SDS-PAGE
Gingipain R1 (rgpA) Recombinant Protein | rgpA recombinant protein
Recombinant Porphyromonas gingivalis Gingipain R1 (rgpA), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Gingipain R1 (rgpA); Recombinant Porphyromonas gingivalis Gingipain R1 (rgpA); partial; Porphyromonas gingivalis; rgpA recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
228-720aa; partial
Sequence
YTPVEEKQNGRMIVIVAKKYEGDIKDFVDWKNQRGLRTEVKVAEDIASPVTANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIVGNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIASAEGGPSADNGESDIQHENVIANLLTQYGYTKIIKCYDPGVTPKNIIDAFNGGISLVNYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVACVNGDFLFSMPCFAEALMRAQKDGKPTGTVAIIASTINQSWASPMRGQDEMNEILCEKHPNNIKRTFGGVTMNGMFAMVEKYKKDGEKMLDTWTVFGDPSLLVRTLVPTKMQVTAPAQINLTDASVNVSCDYNGAIATISANGKMFGSAVVENGTATINLTGLTNESTLTLTVVGYNKETVIKTINTNGEPNPYQPVSNLTATTQGQKVTLKWDAPSTKTNATTNTARSVDGIRELVLLSVSDAPELLRS
Species
Porphyromonas gingivalis
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for rgpA recombinant protein
Thrombin-like snake venom serine protease that acts as an anticoagulant. It cleaves fibrinogen (FGA) to split off the A-fibrinopeptides (A, AY and AP), but not the B-fibrinopeptide. The resulting fibrin polymers are imperfectly formed and much smaller in size (1 to 2 um long) than the fibrin polymers produced by the action of thrombin. These ancrod-induced microthrombi are friable, unstable, urea-soluble and have significantly degraded alpha chains. They do not cross-link to form thrombi. They are markedly susceptible to digestion by plasmin and are rapidly roved from circulation by either reticuloendothelial phagocytosis or normal fibrinolysis, or both. Anticoagulation through the roval of fibrinogen from the blood is rapid, occurring within hours following its administration. It does not activate plasminogen and does not degrade preformed, fully cross-linked thrombin fibrin. It also reduces the level of plasminogen activator inhibitor (PAI) and may stimulate the release of tissue plasminogen activator (PLAT) from the endothelium. The profibrinolytic effect of these 2 actions appears to be limited to local microthrombus degradation.
References
Amino acid sequence determination of ancrod, the thrombin-like alpha-fibrinogenase from the venom of Akistrodon rhodostoma.Burkhart W., Simth G.F.H., Su J.-L., Parikh I., Levine H. IIIFEBS Lett. 297:297-301(1992)
NCBI and Uniprot Product Information
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Product Notes
The rgpA rgpa (Catalog #AAA18540) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 228-720aa; partial. The amino acid sequence is listed below: YTPVEEKQNG RMIVIVAKKY EGDIKDFVDW KNQRGLRTEV KVAEDIASPV TANAIQQFVK QEYEKEGNDL TYVLLVGDHK DIPAKITPGI KSDQVYGQIV GNDHYNEVFI GRFSCESKED LKTQIDRTIH YERNITTEDK WLGQALCIAS AEGGPSADNG ESDIQHENVI ANLLTQYGYT KIIKCYDPGV TPKNIIDAFN GGISLVNYTG HGSETAWGTS HFGTTHVKQL TNSNQLPFIF DVACVNGDFL FSMPCFAEAL MRAQKDGKPT GTVAIIASTI NQSWASPMRG QDEMNEILCE KHPNNIKRTF GGVTMNGMFA MVEKYKKDGE KMLDTWTVFG DPSLLVRTLV PTKMQVTAPA QINLTDASVN VSCDYNGAIA TISANGKMFG SAVVENGTAT INLTGLTNES TLTLTVVGYN KETVIKTINT NGEPNPYQPV SNLTATTQGQ KVTLKWDAPS TKTNATTNTA RSVDGIRELV LLSVSDAPEL LRS . It is sometimes possible for the material contained within the vial of "Gingipain R1 (rgpA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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