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IHC (Immunohistchemistry)
(CTSD/Cathepsin D Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit CTSD/Cathepsin D Polyclonal Antibody | anti-CTSD antibody
CTSD/Cathepsin D Rabbit anti-Human Polyclonal (Internal) Antibody
Gene Names
CTSD; CPSD; CLN10
Reactivity
Mouse, Rat, Pig, Human
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity purified
Synonyms
CTSD/Cathepsin D; Polyclonal Antibody; CTSD/Cathepsin D Rabbit anti-Human Polyclonal (Internal) Antibody; PathPlus CTSD/Cathepsin D Antibody (Internal); CTSD; CPSD; CLN10; Lysosomal aspartyl peptidase; Lysosomal aspartyl protease; ProCathepsin D; CatD; Cathepsin D; anti-CTSD antibody
Host
Rabbit
Reactivity
Mouse, Rat, Pig, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of Cathepsin D LC protein.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, pH7.3, 0.01% Sodium Azide, 30% Glycerol
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CTSD antibody
Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)
Target
Human CTSD/Cathepsin D
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the central region of human Cathepsin D LC.
Conjugation
Unconjugated
Epitope
Internal
Family
Protease
Subfamily
Aspartic A1
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
IHC (Immunohistchemistry)
(CTSD/Cathepsin D Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistchemistry)
(CTSD/Cathepsin D Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSD/Cathepsin D Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(CTSD/Cathepsin D Antibody-Western blot analysis of Cathepsin D LC expression in HepG2 colchicine-treated (A); mouse heart (B); rat heart (C) whole cell lysates.)
WB (Western Blot)
(CTSD/Cathepsin D Antibody-Western blot analysis of Cathepsin D LC expression in HepG2 colchicine-treated (A); mouse heart (B); rat heart (C) whole cell lysates.)
Related Product Information for anti-CTSD antibody
Cathepsin D antibody is an unconjugated rabbit polyclonal antibody to Cathepsin D (CTSD)(Internal) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB.
CTSD (Cathepsin D) is a lysosomal aspartyl protease of the peptidase C1 family that functions to degrade and also activate various intracellular proteins, hormones and growth factors such as VEGFC and VEGFD. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Mutations and deficiency in CTSD lead to neuronal ceroid-lipofuscinosis (NCL). Loss of CTSD expression has been found to cause oxidative damage to pericytes in the brain, increasing permeability of the blood brain barrier and allowing peripheral blood mononuclear cells to infiltrate in lysosomal storage diseases and NCL. In immunohistochemistry of normal tissue, CTSD has granular cytoplasmic positivity throughout the body.
CTSD (Cathepsin D) is a lysosomal aspartyl protease of the peptidase C1 family that functions to degrade and also activate various intracellular proteins, hormones and growth factors such as VEGFC and VEGFD. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Mutations and deficiency in CTSD lead to neuronal ceroid-lipofuscinosis (NCL). Loss of CTSD expression has been found to cause oxidative damage to pericytes in the brain, increasing permeability of the blood brain barrier and allowing peripheral blood mononuclear cells to infiltrate in lysosomal storage diseases and NCL. In immunohistochemistry of normal tissue, CTSD has granular cytoplasmic positivity throughout the body.
References
The Journal of Biological Chemistry. 1989. 264 (23): 13403 -6, PMID: 2760027; Critical Reviews in Oncology/Hematology. 68 (1): 12 -28, PMID: 18396408; Brain. 2006 Jun;129(Pt 6):1353-6, PMID: 16738059; Alzheimer's and Dementia. 2009. 5(4), DOI: 10.1016/j.jalz.2009.04.796; Mol Cell Neurosci. 2015 Jan;64:51-60, PMID: 25496868
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,552 Da
NCBI Official Full Name
cathepsin D preproprotein
NCBI Official Synonym Full Names
cathepsin D
NCBI Official Symbol
CTSD
NCBI Official Synonym Symbols
CPSD; CLN10
NCBI Protein Information
cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10
UniProt Protein Name
Cathepsin D
UniProt Gene Name
CTSD
UniProt Synonym Gene Names
CPSD
UniProt Entry Name
CATD_HUMAN
Similar Products
Product Notes
The CTSD ctsd (Catalog #AAA21355) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CTSD/Cathepsin D Rabbit anti-Human Polyclonal (Internal) Antibody reacts with Mouse, Rat, Pig, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CTSD/Cathepsin D can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB). Researchers should empirically determine the suitability of the CTSD ctsd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CTSD/Cathepsin D, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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