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IHC (Immunohistochemistry)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
Mouse anti-Human, Rat Survivin Monoclonal Antibody | anti-BIRC5 antibody
Survivin Monoclonal Antibody (Mix)
Gene Names
BIRC5; API4; EPR-1
Reactivity
Human, Rat
Applications
Western Blot, Immunohistochemistry
Synonyms
Survivin; Monoclonal Antibody; Survivin Monoclonal Antibody (Mix); BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; anti-BIRC5 antibody
Host
Mouse
Reactivity
Human, Rat
Clonality
Monoclonal
Clone Number
Mix
Applicable Applications for anti-BIRC5 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Cellular Location
Cytoplasm. Nucleus. Chromosome Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody (PubMed:11084331) Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074) Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784).
Tissue Location
Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemistry)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
WB (Western Blot)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
WB (Western Blot)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
WB (Western Blot)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
WB (Western Blot)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry-Paraffin)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry-Paraffin)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry-Paraffin)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
IHC (Immunohistochemistry-Paraffin)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
WB (Western Blot)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
WB (Western Blot)
(Dilution: WB: 1:1000-2000 IHC: 1:200-500)
Related Product Information for anti-BIRC5 antibody
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,389 Da
NCBI Official Full Name
baculoviral IAP repeat-containing protein 5 isoform 2
NCBI Official Synonym Full Names
baculoviral IAP repeat containing 5
NCBI Official Symbol
BIRC5
NCBI Official Synonym Symbols
API4; EPR-1
NCBI Protein Information
baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin
UniProt Protein Name
Baculoviral IAP repeat-containing protein 5
UniProt Gene Name
BIRC5
UniProt Synonym Gene Names
API4; IAP4
UniProt Entry Name
BIRC5_HUMAN
Similar Products
Product Notes
The BIRC5 birc5 (Catalog #AAA28893) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Survivin Monoclonal Antibody (Mix) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Survivin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). Researchers should empirically determine the suitability of the BIRC5 birc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Survivin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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