CD23/FCER2 active protein

Recombinant human CD23/FCER2 protein

Cat. Num. AAA49009

• Gene Names: FCER2; CD23; FCE2; CD23A; IGEBF; CLEC4J
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: CD23/FCER2; N/A; Recombinant human CD23/FCER2 protein; Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD23; CD23A; CLEC4J; FCE2; IGEBF; FCER2; CD23/FCER2 active protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 0.25mg/ml (determined by absorbance at 280nm) (varies by lot)
• Sequence Positions: 48-321aa
• Sequence: Ala; DTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT PSAPLHS

• Applicable Applications for CD23/FCER2 active protein: Bioactivity, SDS-PAGE
• Species: Human
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Tag: His-Tag
• Preparation and Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Related Product Information for CD23/FCER2 active protein

CD23/FCER2, also known as low affinity immunoglobulin epsilon Fc receptor isoform a, is a member of subgroup II of the C-type (Ca++-dependent) lectin superfamily. It is a low affinity receptor for B cell specific antigen and IgE. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. It plays an essential role in the growth and differentiation of B cells, and in the regulation of IgE production. This protein also exists in a soluble secretion form and functions as a powerful cleavage-promoting growth factor. Increased levels of soluble CD23/FCER2 lead to the recruitment of unaffected B cells in the presentation of antigen peptides to allergen-specific B cells. Recombinant human CD23/FCER2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for CD23/FCER2 active protein

Immunology; Proteins

References

Heyman, B., et al. (2000) Annu. Rev. Immunol. 18:709-737.
Bajorath, J., et al. (1996) Protein Sci. 5:240-247.

NCBI and Uniprot Product Information

• NCBI GI #: 20149533
• NCBI GeneID: 2208
• NCBI Accession #: NP_001993.2
• NCBI GenBank Nucleotide #: NM_002002.4
• UniProt Accession #: P06734; Q30219
• Molecular Weight: 36,469 Da
• NCBI Official Full Name: low affinity immunoglobulin epsilon Fc receptor isoform a
• NCBI Official Synonym Full Names: Fc fragment of IgE, low affinity II, receptor for (CD23)
• NCBI Official Symbol: FCER2
• NCBI Official Synonym Symbols: CD23; FCE2; CD23A; IGEBF; CLEC4J
• NCBI Protein Information: low affinity immunoglobulin epsilon Fc receptor; BLAST-2; CD23 antigen; fc-epsilon-RII; lymphocyte IgE receptor; immunoglobulin E-binding factor; C-type lectin domain family 4, member J
• UniProt Protein Name: Low affinity immunoglobulin epsilon Fc receptor
• UniProt Gene Name: FCER2
• UniProt Synonym Gene Names: CD23A; CLEC4J; FCE2; IGEBF
• UniProt Entry Name: FCER2_HUMAN