Structure
(3,3'-Dioctadecyloxacarbocyanine perchlorate, CAS 34215-57-1)
CDK4/6-IN-5 biochemical
CDK4/6-IN-5
Purity
98%
Synonyms
CDK4/6-IN-5; N/A; DiOC18(3); DiO; CDK4/6-IN-5 biochemical
Purity/Purification
98%
CAS
2380321-50-4
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
The CDK4 and CDK6 cell-based IC 50 s of CDK4/6-IN-5 in JEKO-1 and MV4-1 1 cells are 23.8 and 61.4 nM, respectively[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(3,3'-Dioctadecyloxacarbocyanine perchlorate, CAS 34215-57-1)
Structure
(3,3'-Dioctadecyloxacarbocyanine perchlorate, CAS 34215-57-1)
Structure
(3,3'-Dioctadecyloxacarbocyanine perchlorate, CAS 34215-57-1)
Structure
(3,3'-Dioctadecyloxacarbocyanine perchlorate, CAS 34215-57-1)
Related Product Information for CDK4/6-IN-5 biochemical
CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with K i s of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (from patent WO2019207463A1 example A93).
References
1. Warren GL, et al. Redistribution of cell membrane probes following contraction-induced injury of mouse soleus muscle.
2. Bhowmik BB, et al. Photophysical studies of 3,3' dioctadecyloxacarbocyanine dye in model biological membranes and different solvents. Chem Phys Lipids. 2001 Feb;109(2):175-83.
2. Bhowmik BB, et al. Photophysical studies of 3,3' dioctadecyloxacarbocyanine dye in model biological membranes and different solvents. Chem Phys Lipids. 2001 Feb;109(2):175-83.
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Product Notes
The CDK4/6-IN-5 (Catalog #AAA228383) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CDK4/6-IN-5, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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