Structure
(DMAC-SPDB-sulfo, CAS 663599-07-3)
CDK7/9-IN-1 biochemical
CDK7/9-IN-1
Purity
98%
Synonyms
CDK7/9-IN-1; N/A; CDK7/9-IN-1 biochemical
Purity/Purification
98%
CAS
2747919-19-1
Targets&IC50
CDK7:5.74-65.6 nM (IC50), CDK9:2.14 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
CDK7/9-IN-1 (example 8; 0.001-20 uM; 4 h) inhibits CDK7 with an relative IC 50 of 0.0262 uM for phospho-carboxyl terminal domain (Rbp2)(Ser5) in HCT116 cells[1]. CDK7/9-IN-1 (0.001-20 uM; 4 h) inhibits CDK9 with an IC 50 of 2.59 uM for phospho-carboxyl terminal domain (Rbp2)(Ser2) in HCT116 cells[1]. CDK7/9-IN-1 (0.001-20 uM; 4 h) inhibits cMyc with an relative IC 50 of 0.0138 uM in HCT116 cells[1]. CDK7/9-IN-1 (20 uu, 2 uu, and 0.2 uu; 1 h) shows excellent selectivity against the 468 protein kinases panel. CDK7/9-IN-1 shows approximately 96% inhibition against CDK7[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(DMAC-SPDB-sulfo, CAS 663599-07-3)
Structure
(DMAC-SPDB-sulfo, CAS 663599-07-3)
Structure
(DMAC-SPDB-sulfo, CAS 663599-07-3)
Structure
(DMAC-SPDB-sulfo, CAS 663599-07-3)
Related Product Information for CDK7/9-IN-1 biochemical
CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC 50 s of 0.0656 uM and 0.00574 uM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC 50 of 2.14 uM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer.
References
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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Product Notes
The CDK7/9-IN-1 (Catalog #AAA228615) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CDK7/9-IN-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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