Structure
(Casimersen, CAS 1422958-19-7)
Difelikefalin (trifluoroacetate salt) Biochemical
Difelikefalin (trifluoroacetate salt)
Purity
98%
Synonyms
Difelikefalin (trifluoroacetate salt); N/A; SRP-4045; Difelikefalin (trifluoroacetate salt) biochemical
Purity/Purification
98%
Solubility
Ethanol: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Casimersen, CAS 1422958-19-7)
Structure
(Casimersen, CAS 1422958-19-7)
Structure
(Casimersen, CAS 1422958-19-7)
Structure
(Casimersen, CAS 1422958-19-7)
Related Product Information for Difelikefalin (trifluoroacetate salt) biochemical
Difelikefalin is a kappa-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50= 0.048 nM). Difelikefalin is selective for KOR over the u-opioid receptor (MOR; EC50= 1 uM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively).
References
1. Shirley M. Casimersen: First Approval. Drugs. 2021;81(7):875-879.
2. Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150.
2. Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150.
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Product Notes
The Difelikefalin (trifluoroacetate salt) (Catalog #AAA227305) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Difelikefalin (trifluoroacetate salt), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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