Structure
(Vevorisertib, CAS 1416775-46-6)
DPC-AJ1951 (trifluoroacetate salt) Biochemical | DPC-AJ1951 biochemical
DPC-AJ1951 (trifluoroacetate salt)
Purity
98%
Synonyms
DPC-AJ1951 (trifluoroacetate salt); N/A; ARQ 751; DPC-AJ1951 biochemical
Purity/Purification
98%
Solubility
H2O: Slightly soluble
DMSO: Slightly soluble
<1mg/ml refers to the product slightly soluble or insoluble
DMSO: Slightly soluble
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
In vivo, DPC-AJ1951 normalizes serum calcium levels in thyroidparathyroidectomized rats.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Vevorisertib, CAS 1416775-46-6)
Structure
(Vevorisertib, CAS 1416775-46-6)
Structure
(Vevorisertib, CAS 1416775-46-6)
Structure
(Vevorisertib, CAS 1416775-46-6)
Related Product Information for DPC-AJ1951 biochemical
DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants.
References
1. Vevorisertib (ARQ 751)(4440-001) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations.
2. ArQule Presents Recent Data on ARQ 751 at the 2019 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.
3. Abstract A034: The use of biomarkers and ctDNA in a phase 1 trial of ARQ 751
4. Abstract 374: In vitro and in vivo anti-tumor activity of ARQ 751, a potent and selective AKT inhibitor
2. ArQule Presents Recent Data on ARQ 751 at the 2019 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.
3. Abstract A034: The use of biomarkers and ctDNA in a phase 1 trial of ARQ 751
4. Abstract 374: In vitro and in vivo anti-tumor activity of ARQ 751, a potent and selective AKT inhibitor
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Product Notes
The DPC-AJ1951 (Catalog #AAA227296) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DPC-AJ1951 (trifluoroacetate salt), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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