Structure
(Intoplicine dimesylate, CAS 133711-99-6)
Deltorphin II (trifluoroacetate salt) Biochemical
Deltorphin II (trifluoroacetate salt)
Purity
98%
Synonyms
Deltorphin II (trifluoroacetate salt); N/A; RP 60475 dimesylate; Deltorphin II (trifluoroacetate salt) biochemical
Purity/Purification
98%
Solubility
DMSO: 1 mg/mL
DMF:PBS (pH 7.2)(1:5): 0.16 mg/mL
Ethanol: Slightly soluble
DMF: 15 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
DMF:PBS (pH 7.2)(1:5): 0.16 mg/mL
Ethanol: Slightly soluble
DMF: 15 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Intoplicine dimesylate, CAS 133711-99-6)
Structure
(Intoplicine dimesylate, CAS 133711-99-6)
Structure
(Intoplicine dimesylate, CAS 133711-99-6)
Structure
(Intoplicine dimesylate, CAS 133711-99-6)
Related Product Information for Deltorphin II (trifluoroacetate salt) biochemical
Deltorphin II is a peptide agonist of delta2-opioid receptors.1,2It is selective for delta-opioid receptors over u- and kappa-opioid receptors in radioligand bindings assays (Kis = 0.0033, 1, and 1 uM, respectively) and induces [35S]GTPgammaS binding in mouse brain membrane preparations (EC50= 0.034 uM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the delta2-opioid receptor antagonist naltriben but not the delta1-opioid receptor antagonist BNTX.3Intrathecal administration of deltorphin II (15 ug/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.4
References
1. Riou JF, et al. Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities. Cancer Res. 1993;53(24):5987-5993.
2. Eckardt JR, et al. Activity of intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994;86(1):30-33.
3. Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11(4):263-277.
2. Eckardt JR, et al. Activity of intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994;86(1):30-33.
3. Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11(4):263-277.
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Product Notes
The Deltorphin II (trifluoroacetate salt) (Catalog #AAA227199) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Deltorphin II (trifluoroacetate salt), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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