Structure
(Methyl acetate-PEG1, CAS 58349-37-4)
dTAGV-1 TFA Biochemical | dTAGV-1 biochemical
dTAGV-1 TFA
Purity
98%
Synonyms
dTAGV-1 TFA; N/A; dTAGV-1 biochemical
Purity/Purification
98%
CAS
2624313-15-9
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
dTAGV-1 (35 mg/kg; i.p. once daily for 4 days) TFA induces degradation of FKBP12 F36V -Nluc in mice[1]. dTAGV-1 (2-10 mg/kg; i.p.) TFA exhbits half-lives (T 1/2 =3.64 and 4.4 h), C max (595 and 2123 ng/mL) and great exposure (AUC inf =3136 and 18517 h/ng/mL) in mice[1]. dTAGV-1 (2 mg/kg; i.v.) TFA exhbits half-life (T 1/2 =3.02 h), C max (7780 ng/mL) and great exposure (AUC inf =3329 h/ng/mL) in mice[1]. Animal Model: 8-week-old immunocompromised female mice were transplanted with MV4;11 luc-FKBP12 F36V cells[1]. Dosage: 35 mg/kg. Administration: I.p. once daily for 4 days. Result: Observed striking loss of bioluminescent signal 4h after the first and three administrations. Degradation evident 28h after the final administration.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Methyl acetate-PEG1, CAS 58349-37-4)
Structure
(Methyl acetate-PEG1, CAS 58349-37-4)
Structure
(Methyl acetate-PEG1, CAS 58349-37-4)
Structure
(Methyl acetate-PEG1, CAS 58349-37-4)
Related Product Information for dTAGV-1 biochemical
dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12 F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12 F36V -Nluc in vivo.
References
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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Product Notes
The dTAGV-1 (Catalog #AAA228540) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "dTAGV-1 TFA, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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