Structure
((32-Carbonyl)-RMC-5552, CAS 2382768-55-8)
EZH2-IN-4 biochemical
EZH2-IN-4
Purity
98%
Synonyms
EZH2-IN-4; N/A; EZH2-IN-4 biochemical
Purity/Purification
98%
CAS
2088132-99-2
Targets&IC50
mut 5-mer EZH2:2.65 nM (IC50), WT 5-mer EZH2:0.923 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
EZH2-IN-4 (example 38; oral gavage; 15 mpk; BID) results in 73% inhibition of tumor methylation in the Karpas-422 xenograft model[1]. EZH2-IN-4 (po; 50 mpk; twice a day; pretreatment for 5 days; followed by co-administration with gemcitabine plus cisplatin for at least 23 additional days) significant inhibits A2780 tumor growth in A2780 xenograft model[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
((32-Carbonyl)-RMC-5552, CAS 2382768-55-8)
Structure
((32-Carbonyl)-RMC-5552, CAS 2382768-55-8)
Structure
((32-Carbonyl)-RMC-5552, CAS 2382768-55-8)
Structure
((32-Carbonyl)-RMC-5552, CAS 2382768-55-8)
Related Product Information for EZH2-IN-4 biochemical
EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC 50 s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity.
References
1. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.
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Product Notes
The EZH2-IN-4 (Catalog #AAA228088) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EZH2-IN-4, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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