LyP-1 biochemical

LyP-1

Cat. Num. AAA228725

• Purity: 98%
• Synonyms: LyP-1; N/A; Eugeniin; LyP-1 biochemical

• Purity/Purification: 98%

• CAS: 454487-07-1
• Solubility: <1mg/ml refers to the product slightly soluble or insoluble
• In vitro: LyP-1 (8weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide[1].The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×10 6 photon/cm 2 /sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide[1].
• Preparation and Storage: Powder: -20 degree C for 3 years; In solvent: -80 degree C for 2 years

Structure

(Tellimagrandin II, CAS 81571-72-4)

Structure

(Tellimagrandin II, CAS 81571-72-4)

Related Product Information for LyP-1 biochemical

LyP-1 is a cyclic 9?amino?acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells.

References

1. Ruth Niemetz, et al. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry. 2003 Feb;62(3):301-6.
2. Yu-Wei Chang, et al. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. Int J Mol Sci. 2019 Nov 18;20(22):5790.