Structure
(BMS-986224, CAS 2055200-88-7)
QL-X-138 biochemical
QL-X-138
Purity
98%
Synonyms
QL-X-138; N/A; QL-X-138 biochemical
Purity/Purification
98%
CAS
1469988-63-3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
QL-X-138 (72 h) exhibits anti-proliferation activity against lymphoma and leukemia cell lines, with an GI 50 s of 0.31, 1.2, 0.49,1.4, 0.4, 0.23, 0.95, 1.2, 1.4, 0.23, 1.3, 0.93, 1, and 2.4 uM for TMD8, U2932, Ramos, OCI-AML3, SKM-1, NOMO-1, NB4, HEL, U937, NALM6, MEC-1, MEC-2, Hs 505.T and REC-1 cells, respectively[1]. QL-X-138 (0.5-5 uM; 24-72 h) arrests the progression of Ramos, OCI-AML-3, U937 and U2932 cells cycle in a dose dependent manner[1]. QL-X-138 (0.5-5 uM; 8-72 h) induces apoptosis of Ramos, OCI-AML-3, U937 and U2932 cells in a time- and dose-dependent manner[1]. QL-X-138 (3-10000 nM; 4 h) blocks BTK- and MNK-mediated signaling in lymphoma and leukemia cell[1]. Western Blot Analysis[1]Cell Line: Ramos, OCI-AML3, U2932, TMD8 and U937 cells Concentration: 3, 10, 30, 100, 300, 1000, 3000, 10000 nM Incubation Time: 4 hours. Result: Significantly suppressed BTK auto-phosphorylation of Y223 (EC 50 =11 nM). Strongly blocked phosphorylation of the BTK downstream target PLCgamma2 Y1217 (EC 50 =57 nM). Suppressed the phosphorylation of the MNK downstream target eIF4E S209 at a concentration of 1 uM.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(BMS-986224, CAS 2055200-88-7)
Structure
(BMS-986224, CAS 2055200-88-7)
Structure
(BMS-986224, CAS 2055200-88-7)
Structure
(BMS-986224, CAS 2055200-88-7)
Related Product Information for QL-X-138 biochemical
QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC 50 s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti- dengue virus 2 activity, with an IC 50 of 3.5 uM. QL-X-138 can be used for the research of B-cell malignancies.
References
1. Gargalovic P, et al. In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure. Circ Heart Fail. 2021;14(3):e007351.
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Product Notes
The QL-X-138 (Catalog #AAA227743) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "QL-X-138, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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