Structure
(2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, CAS 213473-00-8)
SIM1 biochemical
SIM1
Purity
98%
Synonyms
SIM1; N/A; Meridianin C; SIM1 biochemical
Purity/Purification
98%
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, CAS 213473-00-8)
Structure
(2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, CAS 213473-00-8)
Structure
(2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, CAS 213473-00-8)
Structure
(2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, CAS 213473-00-8)
Related Product Information for SIM1 biochemical
SIM1 is a potent and selective trivalent PROTACDegrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively). SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader. SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells.
Product Categories/Family for SIM1 biochemical
References
1. Kokkaliari S, Pham K, Shahbazi N, Calcul L, Wojtas L, Wilson NG, Crawford AD, Baker BJ. Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp. Mar Drugs. 2022 Mar 8;20(3):196. doi: 10.3390/md20030196. PMID: 35323495; PMCID: PMC8949045.
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Product Notes
The SIM1 (Catalog #AAA228987) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SIM1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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