Tasisulam sodium Biochemical

Tasisulam sodium

Cat. Num. AAA228743

• Purity: 98%
• Synonyms: Tasisulam sodium; N/A; Tasisulam sodium biochemical

• Purity/Purification: 98%

• CAS: 519055-63-1
• Solubility: <1mg/ml refers to the product slightly soluble or insoluble
• In vitro: Tasisulam sodium (200 nM-200 uM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC 50 s of 10 uM and 25 uM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam sodium (25, 50 uM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam sodium (200 nM-200 uM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1]. Cell Proliferation Assay[1]Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 nM-200 uM Incubation Time: 48 hours. Result: Induced an antiproliferative response across a wide range of tumor histologies with EC 50 s is 10 uM and 25 uM, respectively. Cell Cycle Analysis[1]Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 uM Incubation Time: 72 hours. Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1]Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 nM-200 uM Incubation Time: 48 hours. Result: Induced apoptosis in a broad range of in vitro cancer cell models.
• Preparation and Storage: Powder: -20 degree C for 3 years; In solvent: -80 degree C for 2 years

Structure

(Dibromochloroacetamide, CAS 855878-13-6)

Structure

(Dibromochloroacetamide, CAS 855878-13-6)

Related Product Information for Tasisulam sodium biochemical

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization.

References

1. Carter RAA, et, al. Occurrence of disinfection by-products in swimming pools and the estimated resulting cytotoxicity. Sci Total Environ. 2019 May 10;664:851-864.