SDS-PAGE
Botulinum neurotoxin type C1 Recombinant Protein | BoNT/C1 recombinant protein
Recombinant Clostridium botulinum Botulinum neurotoxin type C1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Botulinum neurotoxin type C1; N/A; Recombinant Clostridium botulinum Botulinum neurotoxin type C1; BoNT/C1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-428aa; Partial
Sequence
PITINNFNYSDPVDNKNILYLDTHLNTLANEPEKAFRITGNIWVIPDRFSRNSNPNLNKPPRVTSPKSGYYDPNYLSTDSDKDPFLKEIIKLFKRINSREIGEELIYRLSTDIPFPGNNNTPINTFDFDVDFNSVDVKTRQGNNWVKTGSINPSVIITGPRENIIDPETSTFKLTNNTFAAQEGFGALSIISISPRFMLTYSNATNDVGEGRFSKSEFCMDPILILMHELNHAMHNLYGIAIPNDQTISSVTSNIFYSQYNVKLEYAEIYAFGGPTIDLIPKSARKYFEEKALDYYRSIAKRLNSITTANPSSFNKYIGEYKQKLIRKYRFVVESSGEVTVNRNKFVELYNELTQIFTEFNYAKIYNVQNRKIYLSNVYTPVTANILDDNVYDIQNGFNIPKSNLNVLFMGQNLSRNPALRKVNPEN
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for BoNT/C1 recombinant protein
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves syntaxin.
References
Nucleotide sequence of Clostridium botulinum C1 neurotoxin.Hauser D., Eklund M.W., Kurazona H., Binz T., Niemann H., Gill D.M., Boquet P., Popoff M.R.Nucleic Acids Res. 18:4924-4924(1990) The complete nucleotide sequence of the gene coding for botulinum type C1 toxin in the C-ST phage genome.Kimura K., Fujii N., Tsuzuki K., Murakami T., Indoh T., Yokosawa N., Takeshi K., Syuto B., Oguma K.Biochem. Biophys. Res. Commun. 171:1304-1311(1990) Establishment of a monoclonal antibody recognizing an antigenic site common to Clostridium botulinum type B, C1, D, and E toxins and tetanus toxin.Tsuzuki K., Yokosawa N., Syuto B., Ohishi I., Fujii N., Kimura K., Oguma K.Infect. Immun. 56:898-902(1988) Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.Blasi J., Chapman E.R., Yamasaki S., Binz T., Niemann H., Jahn R.EMBO J. 12:4821-4828(1993)
NCBI and Uniprot Product Information
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Product Notes
The Botulinum neurotoxin type C1 bont/c1 (Catalog #AAA114782) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-428aa; Partial. The amino acid sequence is listed below: PITINNFNYS DPVDNKNILY LDTHLNTLAN EPEKAFRITG NIWVIPDRFS RNSNPNLNKP PRVTSPKSGY YDPNYLSTDS DKDPFLKEII KLFKRINSRE IGEELIYRLS TDIPFPGNNN TPINTFDFDV DFNSVDVKTR QGNNWVKTGS INPSVIITGP RENIIDPETS TFKLTNNTFA AQEGFGALSI ISISPRFMLT YSNATNDVGE GRFSKSEFCM DPILILMHEL NHAMHNLYGI AIPNDQTISS VTSNIFYSQY NVKLEYAEIY AFGGPTIDLI PKSARKYFEE KALDYYRSIA KRLNSITTAN PSSFNKYIGE YKQKLIRKYR FVVESSGEVT VNRNKFVELY NELTQIFTEF NYAKIYNVQN RKIYLSNVYT PVTANILDDN VYDIQNGFNI PKSNLNVLFM GQNLSRNPAL RKVNPEN. It is sometimes possible for the material contained within the vial of "Botulinum neurotoxin type C1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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