CLEC12A / CLL-1 / DCAL2 recombinant protein

Recombinant Human CLEC12A / CLL-1 / DCAL2 Protein (His tag)

Cat. Num. AAA173538

• Gene Names: CLEC12A; CLL1; MICL; CD371; CLL-1; DCAL-2
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Synonyms: CLEC12A / CLL-1 / DCAL2; N/A; Recombinant Human CLEC12A / CLL-1 / DCAL2 Protein (His tag); BDCA2;CD303;CLECSF11;CLECSF7;CLL-1;CLL1;DCAL-2;DLEC;HECL;MICL;PRO34150; CLEC12A / CLL-1 / DCAL2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: > 95 % as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH 7.4, 5% Trehalose, 5% Mannitol, 0.01%Tween-80.

• Species: Human
• Sequence: His 75-Ala 275
• Tag: N-His
• Endotoxin: < 1.0 EU per ug as determined by the LAL method.
• Reconstitution: It is recommended that sterile water(70ul) be added to the vial to prepare a stock solution of 0.15mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Ships on blue ice. Lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-PAGE

Related Product Information for CLEC12A / CLL-1 / DCAL2 recombinant protein

CLEC12A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC12A is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. C-type lectins are the most diverse and prevalent lectin family in immunity. Using a novel CLEC12A -specific monoclonal antibody, experiments had shown that human CLEC12A was expressed primarily on myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells. Although CLEC12A was highly Nglycosylated in primary cells, the level of glycosylation was found to vary between cell types. CLEC12A surface expression was down-regulated during inflammatory/activation conditions in vitro, as well as during an in vivo model of acute inflammation. This suggests that CLEC12A may be involved in the control of myeloid cell activation during inflammation.

NCBI and Uniprot Product Information

• NCBI GI #: 119616538
• NCBI GeneID: 160364
• Molecular Weight: Mol_Mass: 26 kDa; AP_Mol_Mass: 40-45 kDa
• NCBI Official Full Name: C-type lectin domain family 12, member A, isoform CRA_a
• NCBI Official Synonym Full Names: C-type lectin domain family 12 member A
• NCBI Official Symbol: CLEC12A
• NCBI Official Synonym Symbols: CLL1; MICL; CD371; CLL-1; DCAL-2
• NCBI Protein Information: C-type lectin domain family 12 member A
• UniProt Protein Name: C-type lectin domain family 12 member A
• UniProt Gene Name: CLEC12A
• UniProt Synonym Gene Names: CLL1; DCAL2; MICL; CLL-1; DCAL-2; MICL