Syncytin-1 Recombinant Protein | ERVW-1 recombinant protein

Recombinant Human Syncytin-1

Cat. Num. AAA18779

• Gene Names: ERVW-1; ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Syncytin-1; N/A; Recombinant Human Syncytin-1; Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin; Surface protein; SU; gp50; Transmembrane protein; TM; gp24; ERVW-1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 21-443aa; Partial
• Sequence: APPPCRCMTSSSPYQEFLWRMQRPGNIDAPSYRSLSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKMINPSCPGGLGVTVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSVLVGPLVSNLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSAYRCLNGSSESMCFLSFLVPPMTIYTEQDLYSYVISKPRNKRVPILPFVIGAGVLGALGTGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAERGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQ

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for ERVW-1 recombinant protein

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

Product Categories/Family for ERVW-1 recombinant protein

Cell Biology

References

"Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family." Blond J.-L., Beseme F., Duret L., Bouton O., Bedin F., Perron H., Mandrand B., Mallet F. J. Virol. 73:1175-1185(1999)

NCBI and Uniprot Product Information

• NCBI GI #: 195963433
• NCBI GeneID: 30816
• NCBI Accession #: NP_001124397.1
• NCBI GenBank Nucleotide #: NM_001130925.1
• UniProt Accession #: Q9UQF0; O95244; O95245; Q8NHY7; Q9NRZ2; Q9NZG3; B2RPD4
• Molecular Weight: 49 kDa
• NCBI Official Full Name: syncytin-1
• NCBI Official Synonym Full Names: endogenous retrovirus group W member 1
• NCBI Official Symbol: ERVW-1
• NCBI Official Synonym Symbols: ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
• NCBI Protein Information: syncytin-1
• UniProt Protein Name: Syncytin-1
• UniProt Gene Name: ERVW-1
• UniProt Synonym Gene Names: ERVWE1; SU; TM
• UniProt Entry Name: SYCY1_HUMAN