IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded H.placenta tissue reacted with HERV (ERVWE1) Antibody (Center) (Cat# AAA287799).)
Rabbit anti-Human HERV (ERVWE1) Polyclonal Antibody | anti-ERVW-1 antibody
HERV (ERVWE1) Antibody (Center)
Gene Names
ERVW-1; ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Synonyms
HERV (ERVWE1), Antibody; HERV (ERVWE1) Antibody (Center); Syncytin-1; Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q212 provirus ancestral Env polyprotein; Syncytin; Surface protein; SU; gp50; Transmembrane protein; TM; gp24; ERVW-1; ERVWE1; anti-ERVW-1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
This HERV (ERVWE1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the Central region of human HERV (ERVWE1).
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Sequence Positions
400-429
Sequence Length
538
Applicable Applications for anti-ERVW-1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Function
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).
Cellular Location
[Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. [Syncytin-1]: Virion.
Tissue Location
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded H.placenta tissue reacted with HERV (ERVWE1) Antibody (Center) (Cat# AAA287799).)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded H.placenta tissue reacted with HERV (ERVWE1) Antibody (Center) (Cat# AAA287799).)
WB (Western Blot)
(Western blot analysis of lysate from human brain tissue lysate, using Syncytin(ERVWE1) Antibody. AAA287799 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
WB (Western Blot)
(Western blot analysis of lysate from human brain tissue lysate, using Syncytin(ERVWE1) Antibody. AAA287799 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
Related Product Information for anti-ERVW-1 antibody
Background: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The protein, also known as syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. This protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.
Product Categories/Family for anti-ERVW-1 antibody
References
Oluwole,S.O., Amyotroph Lateral Scler 8 (2), 67-72 (2007)
Gong,R., Cell. Physiol. Biochem. 20 (5), 517-526 (2007)
Antony,J.M., AIDS Res. Hum. Retroviruses 22 (12), 1253-1259 (2006)
Gong,R., Cell. Physiol. Biochem. 20 (5), 517-526 (2007)
Antony,J.M., AIDS Res. Hum. Retroviruses 22 (12), 1253-1259 (2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
syncytin-1
NCBI Official Synonym Full Names
endogenous retrovirus group W, member 1
NCBI Official Symbol
ERVW-1
NCBI Official Synonym Symbols
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
NCBI Protein Information
syncytin-1
UniProt Protein Name
Syncytin-1
UniProt Gene Name
ERVW-1
UniProt Synonym Gene Names
ERVWE1; SU; TM
UniProt Entry Name
SYCY1_HUMAN
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Product Notes
The ERVW-1 ervw-1 (Catalog #AAA287799) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 400-429. The HERV (ERVWE1) Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HERV (ERVWE1) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ERVW-1 ervw-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HERV (ERVWE1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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