BAFF R/TNFRSF13C Active Protein | BAFFR/TNFRSF13C active protein

Recombinant human BAFF R/TNFRSF13C protein

Cat. Num. AAA48988

• Gene Names: TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: BAFF R/TNFRSF13C; N/A; Recombinant human BAFF R/TNFRSF13C protein; Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; BROMIX; CD268; CVID4; prolixin; TNFRSF13C; Br3; BAFFR/TNFRSF13C active protein

• Host: HEK293
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 1mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence Positions: 1-78aa
• Sequence: Asp; MRRGPRS LRGRDAPAPT PCVPAECFDL LVRHCVACGL LRTPRPKPAG ASSPAPRTAL QPQESVGAGA GEAALPLPGL L

• Applicable Applications for BAFFR/TNFRSF13C active protein: Bioactivity, SDS-PAGE
• Species: Human
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Tag: hIgG-Tag
• Preparation and Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Related Product Information for BAFFR/TNFRSF13C active protein

BAFFR, also known as TNFRSF13C, is a member of the tumor necrosis factor receptor superfamily. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL, BAFFR selectively binds BAFF. The BAFFR extracellular domain lacks the CRD (TNF receptor canonical cysteine-rich domain and contains only a partial CRD with four cysteine residues. It is highly expressed in spleen, lympHnode and resting B cells and is thought the principal receptor required for BAFF-mediated mature B-cell survival. It has been proposed that abnormally high levels of BAFFR may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. Recombinant human BAFFR, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Categories/Family for BAFFR/TNFRSF13C active protein

Signal Transduction, Growth factors; Proteins

References

Losi CG, et al. (2005) J Clin Immunol. 25:496-502.
Rolink, A.G, et al. (2002) Curr. Opin. Immunol. 14:266-275.

NCBI and Uniprot Product Information

• NCBI GI #: 16445027
• NCBI GeneID: 115650
• NCBI Accession #: NP_443177.1
• NCBI GenBank Nucleotide #: NM_052945.3
• UniProt Accession #: Q96RJ3
• Molecular Weight: 18,935 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 13C
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 13C
• NCBI Official Symbol: TNFRSF13C
• NCBI Official Synonym Symbols: BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 13C; B cell-activating factor receptor; B-cell-activating factor receptor; BAFF receptor; BLyS receptor 3
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 13C
• UniProt Gene Name: TNFRSF13C
• UniProt Synonym Gene Names: BAFFR; BR3; BAFF-R
• UniProt Entry Name: TR13C_HUMAN