FCM/FACS (Flow Cytometry)
(Separation of human monocytes (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD141 (M80) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)
anti-Human CD141 Antibody | anti-CD141 antibody
Anti-Hu CD141 Purified
Gene Names
THBD; TM; THRM; AHUS6; BDCA3; CD141; THPH12
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Synonyms
CD141; N/A; Anti-Hu CD141 Purified; thrombomodulin; Thrombomodulin; fetomodulin; THBD; THRM; THPH12; TM; anti-CD141 antibody
Reactivity
Human
Isotype
Mouse IgG1
Clone Number
M80
Specificity
The mouse monoclonal antibody M80 recognizes an extracellular epitope of CD141, a 75 kDa transmembrane glycoprotein expressed mainly on macrophages, monocytes, platelets and endothelial cells.
Form/Format
Purified
Purified by protein-A affinity chromatography.
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Purified by protein-A affinity chromatography.
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CD141 antibody
FCM/FACS (Flow Cytometry)
Immunogen
MV4-11 cell line
Preparation and Storage
Store at 2-8 degree C. Do not freeze.
FCM/FACS (Flow Cytometry)
(Separation of human monocytes (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD141 (M80) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)
FCM/FACS (Flow Cytometry)
(Separation of human monocytes (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD141 (M80) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)
FCM/FACS (Flow Cytometry)
(Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD141 (M80) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)
FCM/FACS (Flow Cytometry)
(Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD141 (M80) purified antibody (concentration in sample 5 ?g/ml, GAM APC).)
Related Product Information for anti-CD141 antibody
CD141, also known as thrombomodulin or fetomodulin, is a single chain type I transmembrane glycoprotein serving as a receptor for thrombin and as an important cofactor in the protein C anticoagulant system, but it is also involved in embryonic and atherosclerotic plaque development. CD141 is expressed mainly on macrophages, monocytes, a subpopulation of myeloid dendritic cells, on platelets and endothelial cells, but also e.g. on keratinocytes (epithelium). After binding to thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. Mutations in the CD141 gene can cause a thromboembolic disease known as inherited thrombophilia.
References
*Jenner W, Motwani M, Veighey K, Newson J, Audzevich T, Nicolaou A, Murphy S, Macallister R, Gilroy DW: Characterisation of leukocytes in a human skin blister model of acute inflammation and resolution. PLoS One. 2014 Mar 6;9(3):e89375, URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=jenner+w+motwani+m+veighey+k,
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
60,329 Da
NCBI Official Full Name
thrombomodulin
NCBI Official Synonym Full Names
thrombomodulin
NCBI Official Symbol
THBD
NCBI Official Synonym Symbols
TM; THRM; AHUS6; BDCA3; CD141; THPH12
NCBI Protein Information
thrombomodulin; fetomodulin; CD141 antigen
UniProt Protein Name
Thrombomodulin
UniProt Gene Name
THBD
UniProt Synonym Gene Names
THRM; TM
UniProt Entry Name
TRBM_HUMAN
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Product Notes
The CD141 thbd (Catalog #AAA129304) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD141 Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD141 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD141 thbd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD141, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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