Application Data
(The purity of KDM2A was determined to be >90% by densitometry. Approx MW 115kDa)
KDM2A recombinant protein
KDM2A recombinant protein
Gene Names
KDM2A; FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
Applications
Western Blot
Purity
>90%
Synonyms
KDM2A; N/A; KDM2A recombinant protein; CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA; KDM2A protein
Host
Sf9 insect cells
Purity/Purification
>90%
Form/Format
50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.1 mg/ml (varies by lot)
Sequence Positions
1-748
Sequence Length
7393
Applicable Applications for KDM2A recombinant protein
WB (Western Blot)
Type
Recombinant Fusion Protein
Species
Human
Tag Information
GST tag
Expression System
Sf9 insect cells using baculovirus
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Storage: Store product at -70°C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: Ships with dry ice.
Stability: 1 year at -70°C from date of shipment.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: Ships with dry ice.
Stability: 1 year at -70°C from date of shipment.
Application Data
(The purity of KDM2A was determined to be >90% by densitometry. Approx MW 115kDa)
Application Data
(The purity of KDM2A was determined to be >90% by densitometry. Approx MW 115kDa)
Related Product Information for KDM2A recombinant protein
Recombinant human KDM2A (1-748) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: KDM2A or lysine (K)-specific demethylase 2A is a member of the F-box protein family that are components of the modular E3 ubiquitin protein ligases called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2A belongs to the Fbls class and, in addition to the presence of an F-box, contains at least six highly degenerated leucine-rich repeats which play a role in epigenetic silencing. The demethylase activity of the JmjC domain-containing proteins is conserved from yeast to human (2).
Scientific Background: KDM2A or lysine (K)-specific demethylase 2A is a member of the F-box protein family that are components of the modular E3 ubiquitin protein ligases called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2A belongs to the Fbls class and, in addition to the presence of an F-box, contains at least six highly degenerated leucine-rich repeats which play a role in epigenetic silencing. The demethylase activity of the JmjC domain-containing proteins is conserved from yeast to human (2).
Product Categories/Family for KDM2A recombinant protein
References
1. Cenciarelli, C.et.al: Identification of a family of human F-box proteins. Curr. Biol. 9: 1177-1179, 1999.
2. Tsukada, Y. et.al: Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811-816, 2006.
2. Tsukada, Y. et.al: Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811-816, 2006.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
115kDa
NCBI Official Full Name
Homo sapiens lysine (K)-specific demethylase 2A (KDM2A), transcript variant 1, mRNA
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 2A
NCBI Official Symbol
KDM2A
NCBI Official Synonym Symbols
FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
NCBI Protein Information
lysine-specific demethylase 2A; F-box/LRR-repeat protein 11; CXXC-type zinc finger protein 8; [Histone-H3]-lysine-36 demethylase 1A; F-box and leucine-rich repeat protein 11; jumonji C domain-containing histone demethylase 1A; jmjC domain-containing histone demethylation protein 1A
UniProt Protein Name
Lysine-specific demethylase 2A
UniProt Gene Name
KDM2A
UniProt Synonym Gene Names
CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004
UniProt Entry Name
KDM2A_HUMAN
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Product Notes
The KDM2A kdm2a (Catalog #AAA72886) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-748 with tag GST tag!!Expression System||Sf9 insect cells using baculovirus. AAA Biotech's KDM2A can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the KDM2A kdm2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KDM2A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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