SDS-PAGE
Ragulator complex protein LAMTOR1 (LAMTOR1) Recombinant Protein | LAMTOR1 recombinant protein
Recombinant Human Ragulator complex protein LAMTOR1 (LAMTOR1)
Gene Names
LAMTOR1; p18; PDRO; C11orf59; p27RF-Rho; Ragulator1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Ragulator complex protein LAMTOR1 (LAMTOR1); N/A; Recombinant Human Ragulator complex protein LAMTOR1 (LAMTOR1); Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA; p27RF-Rho; LAMTOR1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-161. Full Length of Mature Protein
Sequence
GCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for LAMTOR1 recombinant protein
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Product Categories/Family for LAMTOR1 recombinant protein
References
"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21.6 kDa
NCBI Official Full Name
ragulator complex protein LAMTOR1
NCBI Official Synonym Full Names
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
NCBI Official Symbol
LAMTOR1
NCBI Official Synonym Symbols
p18; PDRO; C11orf59; p27RF-Rho; Ragulator1
NCBI Protein Information
ragulator complex protein LAMTOR1
UniProt Protein Name
Ragulator complex protein LAMTOR1
UniProt Gene Name
LAMTOR1
UniProt Synonym Gene Names
C11orf59; PDRO; p27RF-Rho
UniProt Entry Name
LTOR1_HUMAN
Similar Products
Product Notes
The LAMTOR1 lamtor1 (Catalog #AAA117487) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-161. Full Length of Mature Protein. The amino acid sequence is listed below: GCCYSSENED SDQDREERKL LLDPSSPPTK ALNGAEPNYH SLPSARTDEQ ALLSSILAKT ASNIIDVSAA DSQGMEQHEY MDRARQYSTR LAVLSSSLTH WKKLPPLPSL TSQPHQVLAS EPIPFSDLQQ VSRIAAYAYS ALSQIRVDAK EELVVQFGIP. It is sometimes possible for the material contained within the vial of "Ragulator complex protein LAMTOR1 (LAMTOR1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.