Mouse anti-Human APCS/Serum Amyloid P/SAP Monoclonal Antibody | anti-APCS antibody

APCS/Serum Amyloid P/SAP Mouse anti-Human Monoclonal (7F3) Antibody

Cat. Num. AAA163098

• Gene Names: APCS; SAP; PTX2
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Protein A+G purified to greater than 95% as determined by SDS-PAGE.
• Synonyms: APCS/Serum Amyloid P/SAP, Antibody; APCS/Serum Amyloid P/SAP Mouse anti-Human Monoclonal (7F3) Antibody; PathPlus APCS/Serum Amyloid P/SAP Antibody (clone 7F3); APCS; 9.5S alpha-1-glycoprotein; Amyloid P component; serum; Pentaxin-related; PTX2; Serum Amyloid P; Serum amyloid P-component; SAP; anti-APCS antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7F3
• Purity/Purification: Protein A+G purified to greater than 95% as determined by SDS-PAGE.
• Form/Format: PBS, pH7.3, 0.02% Sodium Azide, 50% Glycerol
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-APCS antibody: WB (Western Blot), IHC (Immunohistochemistry), ELISA
• Target: Human APCS/Serum Amyloid P/SAP
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C for up to 1 year. Avoid freeze/thaw cycles.

IHC (Immunohistochemisry)

(APCS/Serum Amyloid P/SAP Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohiostchemistry)

(APCS/Serum Amyloid P/SAP Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))

IHC (Immunohistochemistry)

(APCS/Serum Amyloid P/SAP Antibody-Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-APCS antibody

SAP antibody is an unconjugated mouse monoclonal antibody to human SAP (APCS/Serum Amyloid P). Validated for ELISA, IHC and WB.
APCS (Serum Amyloid P Component/SAP) is a glycoprotein belonging to the pentraxin family of proteins. In the brain of patients with Alzheimer's disease, APCS binds to amyloid fibrils and paired helical filaments and is present in cerebrospinal fluid, neurofibrillary tangles and amyloid plaques. It is used as a marker for amyloid deposits in immunohistochemistry. Roughly 14% of the dry mass of amyloid deposits is composed of APCS, and it is a likely contributor to the pathogenesis of amyloidosis. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin, and it has been demonstrated that APCS binds to apoptotic cells at an early stage. In immunohistochemistry of normal tissue, APCS is positive in plasma and in hepatocytes in the liver.

References

Nature Medicine. 1997. 3 (8): 855 -9, PMID: 9256275; PLoS One. 2016 Jul 18;11(7):e0159294, PMID: 27428539; Dementia. 1996 Sep-Oct;7(5):256-9, PMID: 8872416; PNAS May 5, 2009 106 (18) 7619-7623; PMID: 10.1073/pnas.0902640106; Cellular and Molecular Pathobiology of Cardiovascular Disease. Academic Press. 2014 Jan. 32. ISBN: 9780124052062;

NCBI and Uniprot Product Information

• NCBI GI #: 4502133
• NCBI GeneID: 325
• NCBI Accession #: NP_001630.1
• NCBI GenBank Nucleotide #: NM_001639
• UniProt Accession #: P02743
• Molecular Weight: 25,387 Da
• NCBI Official Full Name: serum amyloid P-component
• NCBI Official Synonym Full Names: amyloid P component, serum
• NCBI Official Symbol: APCS
• NCBI Official Synonym Symbols: SAP; PTX2
• NCBI Protein Information: serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein
• UniProt Protein Name: Serum amyloid P-component
• UniProt Gene Name: APCS
• UniProt Synonym Gene Names: PTX2; SAP
• UniProt Entry Name: SAMP_HUMAN