Mouse ATRX/RAD54 Monoclonal Antibody | anti-ATRX antibody

ATRX/RAD54 (Alpha Thalassemia Mental Retardation)

Cat. Num. AAA214487

• Gene Names: ATRX; JMS; XH2; XNP; MRX52; RAD54; RAD54L; ZNF-HX
• Reactivity: Human. Others not known.
• Applications: ELISA
• Synonyms: ATRX/RAD54, Antibody; ATRX/RAD54 (Alpha Thalassemia Mental Retardation); Alpha thalassemia/mental retardation syndrome X linked homolog; ATP-dependent helicase ATRX; ATR2; ATRX; DNA-dependent ATPase and helicase; MRXHF1; RAD54; RAD54L; SFM1; SHS; Transcriptional regulator ATRX; X-linked helicase II; X-linked nuclear protein; XH2; XNP; Znf-HX; anti-ATRX antibody

• Host: Mouse
• Reactivity: Human. Others not known.
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: 23c
• Specificity: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 ? to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with ? thalassemia or ATRX syndrome
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 2492

• Applicable Applications for anti-ATRX antibody: ELISA
• Immunogen: Recombinant full-length human ATRX protein
• Cellular Localization: Nuclear
• Hu-chromosome Location: Xq21.1
• Positive Control: Raji, HeLa or A431 Cells. Pancreas, Adrenal, Ovary, Kidney, Prostate or Stomach.
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Pituitary stained with ACTH Mouse Recombinant Monoclonal Antibody (rCLIP/1407).)

SDS-PAGE

(SDS-PAGE Analysis Purified ATRX Mouse Monoclonal Antibody (23c). Confirmation of Integrity and Purity of Antibody.)

References

McDowell et al. 1999. Proc Natl Acad Sci U S A. 96(24):13983-8. Lukashchuk et al. 2008. J Virol. 82(24):12543-54.

NCBI and Uniprot Product Information

• NCBI GI #: 530788276
• NCBI GeneID: 546
• NCBI Accession #: NP_000480.3
• NCBI GenBank Nucleotide #: NM_000489.5
• UniProt Accession #: P46100; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3; D3DTE2
• Molecular Weight: 280kDa
• NCBI Official Full Name: transcriptional regulator ATRX isoform 1
• NCBI Official Synonym Full Names: ATRX, chromatin remodeler
• NCBI Official Symbol: ATRX
• NCBI Official Synonym Symbols: JMS; XH2; XNP; MRX52; RAD54; RAD54L; ZNF-HX
• NCBI Protein Information: transcriptional regulator ATRX
• UniProt Protein Name: Transcriptional regulator ATRX
• UniProt Gene Name: ATRX
• UniProt Synonym Gene Names: RAD54L; XH2; XNP