Dilution Info
Rabbit Brachyury Monoclonal Antibody | anti-Byn antibody
Brachyury, RMab
Gene Names
Byn; trg
Synonyms
Brachyury, Antibody; Brachyury, RMab; Brachyury - Rmab; anti-Byn antibody
Host
Rabbit
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-TBXT
Form/Format
Cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Sequence Length
441
Control
Testis, Chordoma, Chondroma
Localization
Nuclear
Dilution Info
Dilution Info
IHC (Immunohistochemistry)
IHC (Immunohistochemistry)
Related Product Information for anti-Byn antibody
Brachyury is a protein that in humans is encoded by the T gene. Brachyury is a transcription factor within the T-box complex of genes which appears to have a conserved role in defining the midline of a bilaterian organism and thus the establishment of the anterior-posterior axis; this function is apparent in chordates and molluscs. The number of cervical vertebrae is highly conserved among all mammals; however a spontaneous vertebral and spinal dysplasia (VSD) mutation in this gene has been associated with the development of six or fewer cervical vertebrae instead of the usual seven.
Expression of the brachyury gene has been identified as a definitive marker of chordoma, a malignant tumor that arises from remnant notochordal cells lodged in the vertebrae. Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma. The chromosomal region on 6q27 containing the brachyury gene was gained in 6 of 21 chordomas (29%), and none of the 21 chordomas analyzed showed deletions that could have affected this gene.
Brachyury is an important factor in promoting the epithelial-mesenchymal transition (EMT). Cells that over-express brachyury have down-regulated expression of the adhesion molecule E-cadherin, which allows them to undergo EMT. Overexpression of brachyury has been linked to Hepatocellular carcinoma. While brachyury is promoting EMT, it can also induce metastasis of HCC cells. Brachyury expression is a prognostic biomarker for HCC, and the gene may be a target for cancer treatments in the future. Additionally, overexpression of brachyury may play a part in EMT associated with benign disease such as renal fibrosis.
Expression of the brachyury gene has been identified as a definitive marker of chordoma, a malignant tumor that arises from remnant notochordal cells lodged in the vertebrae. Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma. The chromosomal region on 6q27 containing the brachyury gene was gained in 6 of 21 chordomas (29%), and none of the 21 chordomas analyzed showed deletions that could have affected this gene.
Brachyury is an important factor in promoting the epithelial-mesenchymal transition (EMT). Cells that over-express brachyury have down-regulated expression of the adhesion molecule E-cadherin, which allows them to undergo EMT. Overexpression of brachyury has been linked to Hepatocellular carcinoma. While brachyury is promoting EMT, it can also induce metastasis of HCC cells. Brachyury expression is a prognostic biomarker for HCC, and the gene may be a target for cancer treatments in the future. Additionally, overexpression of brachyury may play a part in EMT associated with benign disease such as renal fibrosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
brachyury
NCBI Official Symbol
Byn
NCBI Official Synonym Symbols
trg
NCBI Protein Information
brachyury
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Product Notes
The Byn (Catalog #AAA59309) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Brachyury, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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