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Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using CD103 Mouse Monoclonal Antibody (ITGAE/2063). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse CD103/Integrin alpha E Monoclonal Antibody | anti-CD103 antibody
CD103/Integrin alpha E (T-Cell Lymphoma & Hairy Cell Leukemia Marker)
Gene Names
ITGAE; CD103; HUMINAE
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
CD103/Integrin alpha E, Antibody; CD103/Integrin alpha E (T-Cell Lymphoma & Hairy Cell Leukemia Marker); CD103; Human mucosal lymphocyte antigen 1 (HML1 antigen); Integrin alpha E heavy chain; Integrin alpha E light chain; Integrin alpha E; epithelial-associated; Integrin alpha E1; Integrin alpha-IEL (intestinal intraepithelial lymphocytes); Integrin alpha M290; Integrin alpha-E heavy chain; Integrin; alpha E (ITGAE); anti-CD103 antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG2c, kappa
Clone Number
ITGAE/2063
Specificity
This MAb recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E beta-7 (aEb7) integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Antibody to CD103 is an extremely useful addition to the IHC panel for the hairy cell leukemia (HCL).
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
1179
Applicable Applications for anti-CD103 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant human ITGAE protein fragment
Cellular Localization
Cell Surface and Cytoplasmic
Hu-chromosome Location
17p13
Positive Control
Tonsil, Colon or Stomach
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using CD103 Mouse Monoclonal Antibody (ITGAE/2063). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using CD103 Mouse Monoclonal Antibody (ITGAE/2063). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS_PAGE
(SDS-PAGE Analysis Purified CD103 Mouse Monoclonal Antibody (ITGAE/2063).Confirmation of Purity and Integrity of Antibody.)
SDS_PAGE
(SDS-PAGE Analysis Purified CD103 Mouse Monoclonal Antibody (ITGAE/2063).Confirmation of Purity and Integrity of Antibody.)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Tonsil stained with CD103 Mouse Monoclonal Antibody (ITGAE/2063).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Tonsil stained with CD103 Mouse Monoclonal Antibody (ITGAE/2063).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Small Intestine stained with CD103 Mouse Monoclonal Antibody (ITGAE/2063).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Small Intestine stained with CD103 Mouse Monoclonal Antibody (ITGAE/2063).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Colon stained with CD103 Mouse Monoclonal Antibody (ITGAE/2063).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Colon stained with CD103 Mouse Monoclonal Antibody (ITGAE/2063).)
References
Morgan EA, Yu H, Pinkus JL, Pinkus GS. Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody. Am J Clin Pathol. 2013 Feb; 139(2):220-30.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
150kDa
NCBI Official Full Name
integrin alpha-E
NCBI Official Synonym Full Names
integrin subunit alpha E
NCBI Official Symbol
ITGAE
NCBI Official Synonym Symbols
CD103; HUMINAE
NCBI Protein Information
integrin alpha-E
UniProt Protein Name
Integrin alpha-E
UniProt Gene Name
ITGAE
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Product Notes
The CD103 itgae (Catalog #AAA214658) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD103/Integrin alpha E (T-Cell Lymphoma & Hairy Cell Leukemia Marker) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's CD103/Integrin alpha E can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CD103 itgae for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD103/Integrin alpha E, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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