IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human GIST stained with CD117 Mouse Monoclonal Antibody (C117/370).)
Mouse anti-Human. CD117 Monoclonal Antibody | anti-KIT antibody
CD117 / c-Kit
Gene Names
KIT; PBT; SCFR; C-Kit; CD117
Reactivity
Human.
Applications
Immunohistochemistry
Synonyms
CD117, Antibody; CD117 / c-Kit; p145; Steel Factor Receptor; Stem Cell Factor Receptor (SCF-Receptor); Mast Cell Growth Factor Receptor; anti-KIT antibody
Host
Mouse
Reactivity
Human.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
C117/370
Specificity
This MAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
976
Applicable Applications for anti-KIT antibody
IHC (Immunohistochemistry)
Localization
Cell surface and cytoplasmic
Positive Control
Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Human Chromosomal Location
4q12
Immunogen
Recombinant human CD117 protein
Quantity and Buffer
0.5 ml at 200ug/ml with BSA and azide
Preparation and Storage
Store at 2 to 8 degree C. Antibody is stable for 24 months.
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human GIST stained with CD117 Mouse Monoclonal Antibody (C117/370).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human GIST stained with CD117 Mouse Monoclonal Antibody (C117/370).)
SDS-PAGE
(SDS-PAGE Analysis Purified CD117 Mouse Monoclonal Antibody (C117/370).)
SDS-PAGE
(SDS-PAGE Analysis Purified CD117 Mouse Monoclonal Antibody (C117/370).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human GIST stained with CD117 Mouse Monoclonal Antibody (C117/370).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human GIST stained with CD117 Mouse Monoclonal Antibody (C117/370).)
References
1. Zafrani B, et. al. Histopathology 2000; 37(6), 536-545.
2. Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 1474-1481.
2. Harvey JM, et. al. Journal of Clinical Oncology 1999; 17(5), 1474-1481.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~145kDa
NCBI Official Full Name
mast/stem cell growth factor receptor Kit isoform 1
NCBI Official Synonym Full Names
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
NCBI Official Symbol
KIT
NCBI Official Synonym Symbols
PBT; SCFR; C-Kit; CD117
NCBI Protein Information
mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
UniProt Protein Name
Mast/stem cell growth factor receptor Kit
UniProt Gene Name
KIT
UniProt Synonym Gene Names
SCFR; SCFR; PBT
UniProt Entry Name
KIT_HUMAN
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Product Notes
The KIT kit (Catalog #AAA62592) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD117 / c-Kit reacts with Human. and may cross-react with other species as described in the data sheet. AAA Biotech's CD117 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the KIT kit for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD117, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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