Rat anti-Mouse CD117/c-Kit Monoclonal Antibody
Rat Anti-Mouse CD117/c-kit-FITC
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD117/c-Kit, Antibody; Rat Anti-Mouse CD117/c-kit-FITC; c-Kit, mast cell growth factor, stem cell factor, steel factor, SCF; anti-CD117/c-Kit antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat (Wistar) IgG2b κ
Clone Number
2B8
Specificity
Mouse CD117; Mr 150 kDa
Form/Format
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3.
Concentration
0.05 mg/ml (varies by lot)
Applicable Applications for anti-CD117/c-Kit antibody
FCM/FACS (Flow Cytometry)
Immunogen
Mouse IL-3-dependent bone marrow mast cells
Preparation and Storage
Store at 2-8°C.
Related Product Information for anti-CD117/c-Kit antibody
Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.
References
1. Broudy, V.C., et al, 1996. Blood 88:75.
2. Veiby, O.P., S. D. Lyman and S. E. Jacobsen. 1996. Blood 87:3117.
3. Sudo, T., et al. 1995. Oncogene 11:2469.
4. Yoshida, H., et al. 1996. Development 122: 1207.
2. Veiby, O.P., S. D. Lyman and S. E. Jacobsen. 1996. Blood 87:3117.
3. Sudo, T., et al. 1995. Oncogene 11:2469.
4. Yoshida, H., et al. 1996. Development 122: 1207.
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Product Notes
The CD117/c-Kit (Catalog #AAA78687) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse CD117/c-kit-FITC reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD117/c-Kit can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD117/c-Kit for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD117/c-Kit, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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