Mouse anti-Human CD152 Monoclonal Antibody | anti-CD152 antibody
Anti-Hu CD152 PE-Cyanine5
Gene Names
CTLA4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
The purified antibody is conjugated with tandem dye PE-Cyanine5 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Synonyms
CD152, Antibody; Anti-Hu CD152 PE-Cyanine5; cytotoxic T-lymphocyte associated protein 4; CTLA4; GSE; GRD4; anti-CD152 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
BNI3
Specificity
The mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses.
Purity/Purification
The purified antibody is conjugated with tandem dye PE-Cyanine5 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Sequence Length
223
Applicable Applications for anti-CD152 antibody
FCM/FACS (Flow Cytometry)
Immunogen
Human CD152-IgG heavy chain fusion protein
Conjugation
PE-Cyanine5
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Related Product Information for anti-CD152 antibody
CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Cytotoxic T-lymphocyte protein 4
NCBI Official Synonym Full Names
cytotoxic T-lymphocyte associated protein 4
NCBI Official Symbol
CTLA4
NCBI Official Synonym Symbols
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
NCBI Protein Information
cytotoxic T-lymphocyte protein 4
UniProt Protein Name
Cytotoxic T-lymphocyte protein 4
UniProt Gene Name
CTLA4
UniProt Synonym Gene Names
CD152; CTLA-4
UniProt Entry Name
CTLA4_HUMAN
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Product Notes
The CD152 ctla4 (Catalog #AAA128449) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD152 PE-Cyanine5 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD152 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD152 ctla4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD152, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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