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SDS_PAGE
(SDS-PAGE Analysis Purified CD40 Mouse Monoclonal Antibody (C40/1605). Confirmation of Integrity and Purity of Antibody.)
Mouse CD40/TNFRSF5/CD40L-Receptor Monoclonal Antibody | anti-CD40 antibody
CD40/TNFRSF5/CD40L-Receptor
Gene Names
CD40; p50; Bp50; CDW40; TNFRSF5
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
CD40/TNFRSF5/CD40L-Receptor, Antibody; CD40/TNFRSF5/CD40L-Receptor; B-cell surface antigen CD40; Bp50; CD40; CD40L receptor; GP39; HIGM1; IGM; IMD3; p50; TBAM; TNF receptor superfamily member 5; TNFRSF5; TRAP; anti-CD40 antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
C40/1605
Specificity
CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
277
Applicable Applications for anti-CD40 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant full-length human CD40 protein
Cellular Localization
Cell Surface and Secreted
Hu-chromosome Location
20q12-q13.2
Positive Control
L-428 Cells. Tonsil, Spleen or Thymus
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
SDS_PAGE
(SDS-PAGE Analysis Purified CD40 Mouse Monoclonal Antibody (C40/1605). Confirmation of Integrity and Purity of Antibody.)
SDS_PAGE
(SDS-PAGE Analysis Purified CD40 Mouse Monoclonal Antibody (C40/1605). Confirmation of Integrity and Purity of Antibody.)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Tonsil stained with CD40 Mouse Monoclonal Antibody (C40/1605).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Tonsil stained with CD40 Mouse Monoclonal Antibody (C40/1605).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Spleen stained with CD40 Mouse Monoclonal Antibody (C40/1605).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Spleen stained with CD40 Mouse Monoclonal Antibody (C40/1605).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with CD40 Mouse Monoclonal Antibody (C40/1605).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with CD40 Mouse Monoclonal Antibody (C40/1605).)
References
Kehry, M.R., et al. 1994. B cell activation by helper T cell membranes. Crit. Rev. Immunol. 14: 221-238.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43kDa
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 5 isoform 1
NCBI Official Synonym Full Names
CD40 molecule
NCBI Official Symbol
CD40
NCBI Official Synonym Symbols
p50; Bp50; CDW40; TNFRSF5
NCBI Protein Information
tumor necrosis factor receptor superfamily member 5
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 5
UniProt Gene Name
CD40
UniProt Synonym Gene Names
TNFRSF5
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Product Notes
The CD40 cd40 (Catalog #AAA214600) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD40/TNFRSF5/CD40L-Receptor reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's CD40/TNFRSF5/CD40L-Receptor can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CD40 cd40 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD40/TNFRSF5/CD40L-Receptor, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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