IHC (Immunohiostchemistry)
(CD42b Antibody Immunohistochemistry on an FFPE Bone Marrow Tissue)
Rabbit anti-Human CD42b Monoclonal Antibody | anti-CD42b antibody
CD42b, RMab (EP409)
Reactivity
Human
Synonyms
CD42b, Antibody; CD42b, RMab (EP409); GP1BA; Antigen CD42b alpha; BSS; CD42B; CD42b alpha; anti-cd42b; anti cd42b; Glycocalicin; glycoprotein Ib platelet alpha polypeptide; Glycoprotein Ibalpha; GP Ib alpha; GP1B; GPIb alpha; GPIbA; MGC34595; platelet glycoprotein Ib alpha chain; platelet membrane glycoprotein 1b alpha subunit; BDPLT1; BDPLT3; DBPLT3; VWDP; anti-CD42b antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP409
Form/Format
Paraffin, Frozen
CD42b is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CD42b is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
A synthetic peptide corresponding to residues of human CD42b protein.
Control
Bone Marrow, Spleen
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(CD42b Antibody Immunohistochemistry on an FFPE Bone Marrow Tissue)
IHC (Immunohiostchemistry)
(CD42b Antibody Immunohistochemistry on an FFPE Bone Marrow Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-CD42b antibody
CD42b Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide is a protein that in humans is encoded by the GP1BA gene. The Gp Ib functions as a receptor for von Willebrand factor (VWF), which includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease (1).
CD42b antibody is a marker of megakaryocytes and platelets and used in the identification of AML-M7 to distinguish AML-M7 (CD42b+) from acute myelosis with myelofibrosis (usually CD42b -). Acute megakaryoblastic leukemia has a significantly higher proportion of blasts expressing CD42b (2). Patients with Histoplasma capsulatum infections have been noted with unusual IHC positivity of the platelet associated marker CD42b/GP1b expressed on the surface of this fungal organisms. Evaluation of additional cases demonstrated that a majority of histoplasmosis cases (83%) showed positive staining with CD42b/GP1b, comparable to GMS stain results (3).
CD42b antibody is a marker of megakaryocytes and platelets and used in the identification of AML-M7 to distinguish AML-M7 (CD42b+) from acute myelosis with myelofibrosis (usually CD42b -). Acute megakaryoblastic leukemia has a significantly higher proportion of blasts expressing CD42b (2). Patients with Histoplasma capsulatum infections have been noted with unusual IHC positivity of the platelet associated marker CD42b/GP1b expressed on the surface of this fungal organisms. Evaluation of additional cases demonstrated that a majority of histoplasmosis cases (83%) showed positive staining with CD42b/GP1b, comparable to GMS stain results (3).
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Product Notes
The CD42b (Catalog #AAA59337) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD42b, RMab (EP409) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD42b, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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