Rabbit Cytokeratin 5/KRT5 Monoclonal Antibody | anti-KRT5 antibody

Recombinant Anti-Cytokeratin 5/KRT5 Antibody, Rabbit Monoclonal

Cat. Num. AAA254192

• Gene Names: KRT5; K5; CK5; DDD; EBS2; KRT5A
• Reactivity: Human; Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A
• Synonyms: Cytokeratin 5/KRT5, Antibody; Recombinant Anti-Cytokeratin 5/KRT5 Antibody, Rabbit Monoclonal; KRT5 Antibody, Rabbit MAb; keratin 5, type II; Anti-CK5 Antibody; Anti-DDD Antibody; Anti-DDD1 Antibody; Anti-EBS2 Antibody; Anti-K5 Antibody; Anti-KRT5A Antibody; anti-KRT5 antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 104
• Specificity: Human Cytokeratin 5/KRT5
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-KRT5 antibody: IHC (Immunohistochemistry)
• Antibody Type: Recombinant Antibody
• Immunogen: A synthetic peptide corresponding to the center region of the human KRT5
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the human KRT5.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohistochemisry)

(Immunochemical staining of human CK5 in human breast carcinoma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).)

IHC (Immunohiostchemistry)

(Immunochemical staining of human CK5 in human gastric cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).)

IHC (Immunohistochemistry)

(Immunochemical staining of human CK5 in human skin with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-KRT5 antibody

Keratin 5 is the major type II keratin of the basal cells of the epidermis and other stratified epithelia. With its type I partner, keratin 14, it constitutes a major fraction of the cytoskeleton of the basal cells. Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is a rare dermatologic disorder of autosomal dominant inheritance with intraepidermal blistering after minor trauma, reticular hyperpigmentation unrelated to the blistering, nail dystrophy, and mild palmoplantar keratosis. Keratin 5 and keratin 14 are known to be essential for the basal keratinocyte cytoskeleton and are defective in several forms of epidermolysis bullosa simplex. Recently, a 71C-->T transition in the keratin 5 gene (KRT5) causing a P24L substitution was identified in some patients with EBS-MP.

NCBI and Uniprot Product Information

• NCBI GI #: 119395754
• NCBI GeneID: 3852
• NCBI Accession #: NP_000415.2
• NCBI GenBank Nucleotide #: NM_000424.3
• UniProt Accession #: P13647; Q6PI71; Q6UBJ0; Q8TA91
• Molecular Weight: 62,378 Da
• NCBI Official Full Name: keratin, type II cytoskeletal 5
• NCBI Official Synonym Full Names: keratin 5
• NCBI Official Symbol: KRT5
• NCBI Official Synonym Symbols: K5; CK5; DDD; EBS2; KRT5A
• NCBI Protein Information: keratin, type II cytoskeletal 5; CK-5; cytokeratin-5; 58 kda cytokeratin; type-II keratin Kb5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)
• UniProt Protein Name: Keratin, type II cytoskeletal 5
• UniProt Gene Name: KRT5
• UniProt Synonym Gene Names: CK-5; K5
• UniProt Entry Name: K2C5_HUMAN