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Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse Cytokeratin 6A (KRT6A) Monoclonal Antibody | anti-KRT6A antibody
Cytokeratin 6A (KRT6A) (Basal Cell Marker)
Gene Names
KRT6A; K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
Cytokeratin 6A (KRT6A), Antibody; Cytokeratin 6A (KRT6A) (Basal Cell Marker); 58kDa Cytokeratin; CK5; Cytokeratin-5; DDD1; Epidermolysis Bullosa Simplex 2 (EBS2); Keratin 5; Keratin, Type II Cytoskeletal 5; Keratin-5; KRT5; Type-II Cytoskeletal 5; Type-II keratin Kb5; anti-KRT6A antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
KRT6A/2368
Specificity
This MAb recognizes a protein of 56kDa, identified as cytokeratin 6A (KRT6A). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Cytokeratin 6A is the dominant form in epithelial tissue. Cytokeratin 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express KRT6 and KRT16. KRT6 is strongly expressed in about 75% of head and neck squamous cell carcinomas..
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
564
Applicable Applications for anti-KRT6A antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant full-length human Cytokeratin 6A (KRT6A) protein
Cellular Localization
Cytoplasmic
Hu-chromosome Location
12q13.13
Positive Control
Tonsil or Basal Cell Carcinoma (BCC)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS_PAGE
(SDS-PAGE Analysis Purified Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368). Confirmation of Integrity and Purity of Antibody)
SDS_PAGE
(SDS-PAGE Analysis Purified Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368). Confirmation of Integrity and Purity of Antibody)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).)
IHC (Immunohistochemisry)
(Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Basal Cell stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Basal Cell stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).)
References
Stephens, K., et al. 1995. Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton function. Am. J. Hum. Genet. 56: 577-585.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
56kDa
NCBI Official Full Name
keratin, type II cytoskeletal 6C
NCBI Official Synonym Full Names
keratin 6A
NCBI Official Symbol
KRT6A
NCBI Official Synonym Symbols
K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D
NCBI Protein Information
keratin, type II cytoskeletal 6C
UniProt Protein Name
Keratin, type II cytoskeletal 6A
UniProt Gene Name
KRT6A
UniProt Synonym Gene Names
K6A; KRT6D; CK-6A; CK-6D; K6A
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Product Notes
The KRT6A krt6a (Catalog #AAA214661) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cytokeratin 6A (KRT6A) (Basal Cell Marker) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's Cytokeratin 6A (KRT6A) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the KRT6A krt6a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytokeratin 6A (KRT6A), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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