Mouse anti-Human DNMT1/DNA Methyltransferase 1 Monoclonal Antibody | anti-DNMT1 antibody

DNMT1/DNA Methyltransferase 1

Cat. Num. AAA214927

• Gene Names: DNMT1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: DNMT1/DNA Methyltransferase 1, Antibody; DNMT1/DNA Methyltransferase 1; ADCADN; AIM; CXXC-type zinc finger protein 9; CXXC9; DNA methyltransferase 1 (DNMT1); HSN1E; MCMT; Met1; MommeD2; anti-DNMT1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b, kappa
• Clone Number: DNMT1/2061
• Specificity: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 1616

• Applicable Applications for anti-DNMT1 antibody: IHC (Immunohistochemistry)
• Positive Control: Raji cells. Tonsil or Placenta.
• Immunogen: Recombinant human DNMT1 protein fragment (around aa 767-912) (exact sequence is proprietary)
• Cellular Localization: Nuclear
• Hu-chromosome Location: 19p13.2
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified DNMT1 Mouse Monoclonal Antibody (DNMT1/2061). Confirmation of Integrity and Purity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with DNMT1 Mouse Monoclonal Antibody (DNMT1/2061).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Placenta stained with DNMT1 Mouse Monoclonal Antibody (DNMT1/2061).)

References

1. Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene 242: 407-41. 2. Bigey, P., Ramchandani, S., Theberge, J., Araujo, F.D. and Szyf, M. 2000

NCBI and Uniprot Product Information

• NCBI GI #: 12231019
• NCBI GeneID: 1786
• UniProt Accession #: P26358
• Molecular Weight: 184kDa
• NCBI Official Full Name: DNA (cytosine-5)-methyltransferase 1
• NCBI Official Synonym Full Names: DNA methyltransferase 1
• NCBI Official Symbol: DNMT1
• NCBI Official Synonym Symbols: AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
• NCBI Protein Information: DNA (cytosine-5)-methyltransferase 1
• UniProt Protein Name: DNA (cytosine-5)-methyltransferase 1
• UniProt Gene Name: DNMT1
• UniProt Synonym Gene Names: AIM; CXXC9; DNMT; Dnmt1; DNA MTase HsaI; M.HsaI
• UniProt Entry Name: DNMT1_HUMAN