FCM/FACS (Flow Cytometry)
(1,1-Phenanthroline stimulated human peripheral blood monocytes were stained with Mouse Anti-Himan Fas Ligand-FITC.)
Mouse anti-Human Fas Ligand (CD178) Monoclonal Antibody | anti-FASLG antibody
Mouse Anti-Human Fas Ligand-FITC
Gene Names
FASLG; FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Synonyms
Fas Ligand (CD178), Antibody; Mouse Anti-Human Fas Ligand-FITC; Mouse Anti-Human Fas Ligand - FITC; Mouse anti-Human Fas Ligand (CD178); anti-FASLG antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2bK
Clone Number
SB93a
Specificity
Human/Chicken Fas ligand
Form/Format
Fluorescein (FITC) Conjugate
Sequence Length
281
Applicable Applications for anti-FASLG antibody
FCM/FACS (Flow Cytometry)
Immunogen
Recombinant human Fas Ligand
Characterization
To ensure acceptable performance, each batch of product is tested by Flow Cytometry and/or Western blotting to conform to characteristics of a standard reference reagent.
Preparation and Storage
The fluorescein (FITC) conjugate is supplied as 0.1mg in 0.2mL of PBS/NaN3. Store at 2- 8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
Reagents are stable for the period shown on the label if stored as directed.
FCM/FACS (Flow Cytometry)
(1,1-Phenanthroline stimulated human peripheral blood monocytes were stained with Mouse Anti-Himan Fas Ligand-FITC.)
FCM/FACS (Flow Cytometry)
(1,1-Phenanthroline stimulated human peripheral blood monocytes were stained with Mouse Anti-Himan Fas Ligand-FITC.)
Related Product Information for anti-FASLG antibody
Fas Ligand (CD178) is a 40 kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells2,3. Moreover, studies indicate that Fas Ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death4. Fas Ligand initiates apoptosis by binding to its receptor (CD95) on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase- 85.
The SB93a monoclonal antibody detects a band at ~40 kD, corresponding to the transmembrane (insoluble) form of Fas Ligand.
The SB93a monoclonal antibody detects a band at ~40 kD, corresponding to the transmembrane (insoluble) form of Fas Ligand.
References
1) Trambas, C.M. and Griffiths, G.M. (2003) Nat. Immunol. 4:399-403.
3) Voss, M. et al. (2008). Cell. Commun. Signal. 6:11.
4) Krammer, P.H. (2000). Nature. 407:789-95..
5) Peter, M.E. and Krammer, P.H. (2002). Cell. Death Diff. 10:26-35.
3) Voss, M. et al. (2008). Cell. Commun. Signal. 6:11.
4) Krammer, P.H. (2000). Nature. 407:789-95..
5) Peter, M.E. and Krammer, P.H. (2002). Cell. Death Diff. 10:26-35.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Fas ligand (TNF superfamily, member 6)
NCBI Official Synonym Full Names
Fas ligand (TNF superfamily, member 6)
NCBI Official Symbol
FASLG
NCBI Official Synonym Symbols
FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 6
UniProt Gene Name
FASLG
UniProt Synonym Gene Names
APT1LG1; CD95L; FASL; TNFSF6
UniProt Entry Name
TNFL6_HUMAN
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Product Notes
The FASLG faslg (Catalog #AAA78622) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human Fas Ligand-FITC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fas Ligand (CD178) can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the FASLG faslg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fas Ligand (CD178), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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