Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using GP2 Mouse Monoclonal Antibody (GP2/1805) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse GP2 (Glycoprotein 2)/ZAP75 Monoclonal Antibody | anti-GP2 antibody
GP2 (Glycoprotein 2)/ZAP75
Gene Names
GP2; ZAP75
Reactivity
Human. Others not known.
Applications
Immunohistochemistry, ELISA
Synonyms
GP2 (Glycoprotein 2)/ZAP75, Antibody; GP2 (Glycoprotein 2)/ZAP75; Glycoprotein 2 (zymogen granule membrane); GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75; anti-GP2 antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG2c, kappa
Clone Number
GP2/1805
Specificity
GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
537
Applicable Applications for anti-GP2 antibody
IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant fragment of human GP2 protein (around aa 35-179)
Cellular Localization
Cell Surface and Secreted
Hu-chromosome Location
16p12
Positive Control
PANC-1 Cells. Pancreas
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using GP2 Mouse Monoclonal Antibody (GP2/1805) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19, 000 full-length human proteins using GP2 Mouse Monoclonal Antibody (GP2/1805) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS-PAGE
(SDS-PAGE Analysis Purified GP2 Mouse Monoclonal Antibody (GP2/1805). Confirmation of Purity and Integrity.)
SDS-PAGE
(SDS-PAGE Analysis Purified GP2 Mouse Monoclonal Antibody (GP2/1805). Confirmation of Purity and Integrity.)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded Human Pancreas stained with GP2 Mouse Monoclonal Antibody (GP2/1805).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded Human Pancreas stained with GP2 Mouse Monoclonal Antibody (GP2/1805).)
References
Fukuoka, S., et al. 1991. Proc. Natl. Acad. Sci. USA 88: 2898-2902.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59kDa
NCBI Official Full Name
pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein
NCBI Official Synonym Full Names
glycoprotein 2
NCBI Official Symbol
GP2
NCBI Official Synonym Symbols
ZAP75
NCBI Protein Information
pancreatic secretory granule membrane major glycoprotein GP2
UniProt Protein Name
Pancreatic secretory granule membrane major glycoprotein GP2
UniProt Gene Name
GP2
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Product Notes
The GP2 gp2 (Catalog #AAA214653) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GP2 (Glycoprotein 2)/ZAP75 reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's GP2 (Glycoprotein 2)/ZAP75 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the GP2 gp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GP2 (Glycoprotein 2)/ZAP75, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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