Rabbit GP2 (Glycoprotein 2)/ZAP75 Monoclonal Antibody | anti-GP2 antibody

GP2 (Glycoprotein 2)/ZAP75

Cat. Num. AAA214751

• Gene Names: GP2; ZAP75
• Reactivity: Human.; Does not react with Mouse. Others not known.
• Applications: Immunohistochemistry, ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: GP2 (Glycoprotein 2)/ZAP75, Antibody; GP2 (Glycoprotein 2)/ZAP75; Glycoprotein 2 (zymogen granule membrane); GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75; anti-GP2 antibody

• Host: Rabbit
• Reactivity: Human.; Does not react with Mouse. Others not known.
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: GP2/2569R
• Specificity: GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 390

• Applicable Applications for anti-GP2 antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant human GP2 protein fragment (around aa35-179) (exact sequence is proprietary)
• Positive Control: PANC-1 Cells. Pancreas
• Cellular Localization: Cell Surface and Secreted
• Chromosome Location: 16p12
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified GP2 Recombinant Rabbit Monoclonal Antibody (GP2/2569R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded Human Pancreas stained with GP2 Recombinant Rabbit Monoclonal Antibody (GP2/2569R).)

Related Product Information for anti-GP2 antibody

Recombinant Rabbit Monoclonal Antibody

References

Fukuoka, S., et al. 1991. A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes. Proc. Natl. Acad. Sci. USA 88: 2898-2902.

NCBI and Uniprot Product Information

• NCBI GI #: 119220569
• NCBI GeneID: 2813
• NCBI Accession #: NP_001007241.2
• NCBI GenBank Nucleotide #: NM_001007240.2
• UniProt Accession #: P55259; Q13338; Q9UIF1; A6NFM9; A6NJA8
• Molecular Weight: 59kDa
• NCBI Official Full Name: pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein
• NCBI Official Synonym Full Names: glycoprotein 2
• NCBI Official Symbol: GP2
• NCBI Official Synonym Symbols: ZAP75
• NCBI Protein Information: pancreatic secretory granule membrane major glycoprotein GP2
• UniProt Protein Name: Pancreatic secretory granule membrane major glycoprotein GP2
• UniProt Gene Name: GP2