Mouse anti-Human HLA-G (Major Histocompatibility Complex, class I, G) Monoclonal Antibody | anti-HLA-G antibody

HLA-G (Major Histocompatibility Complex, class I, G) Mouse Monoclonal Antibody [Clone HLAG/6686]

Cat. Num. AAA215702

• Gene Names: HLA-G; MHC-G
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Synonyms: HLA-G (Major Histocompatibility Complex, class I, G), Antibody; HLA-G (Major Histocompatibility Complex, class I, G) Mouse Monoclonal Antibody [Clone HLAG/6686]; B2 microglobulin; DADB-15K14. 8; HLA 6. 0; HLA G histocompatibility antigen class I G; HLA G3; HLA60; HLAG; Major histocompatibility complex class I G; MHC class I antigen G; MHC G; T-cell A locus; TCA; anti-HLA-G antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse/IgG1, kappa
• Clone Number: HLAG/6686
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Concentration: Purified Ab with BSA and Azide at 200ug/ml; OR; Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)

• Applicable Applications for anti-HLA-G antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Purified His-tagged HLA-G protein.
• Cellular Localization: Cell surface
• Positive Control: Raji cells. Expressed in trophoblasts.
• Hu-chromosome Location: 6p22.1
• Unigene: 512152
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human prostate stained with HLA-G Mouse Monoclonal Antibody (HLAG/6686) at 2ug/ml. Inset: PBS instead of primary antibody, secondary negative control.)

Related Product Information for anti-HLA-G antibody

Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, beta2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 122132
• NCBI GeneID: 3135
• UniProt Accession #: P17693
• Molecular Weight: 338
• NCBI Official Full Name: HLA class I histocompatibility antigen, alpha chain G
• NCBI Official Synonym Full Names: major histocompatibility complex, class I, G
• NCBI Official Symbol: HLA-G
• NCBI Official Synonym Symbols: MHC-G
• NCBI Protein Information: HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G
• UniProt Protein Name: HLA class I histocompatibility antigen, alpha chain G
• UniProt Gene Name: HLA-G
• UniProt Synonym Gene Names: HLA-6.0; HLAG
• UniProt Entry Name: HLAG_HUMAN