IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human placenta tissue slide using LIFR Monoclonal Antibody at dilution of 1:60.Positive staining was localized to trophoblast.)
Mouse anti-Human LIFR/CD118 Monoclonal Antibody | anti-LIFR/CD118 antibody
Mouse anti Human LIFR/CD118 Monoclonal Antibody
Gene Names
LIFR; SWS; SJS2; STWS; CD118; LIF-R
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A.
Synonyms
LIFR/CD118, Antibody; Mouse anti Human LIFR/CD118 Monoclonal Antibody; CD118, LIFR,STWS; anti-LIFR/CD118 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Purity/Purification
Protein A.
Sequence Length
1097
Applicable Applications for anti-LIFR/CD118 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant Human LIFR protein
Buffer
0.2 um filtered solution in PBS
Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store at -20°C. Avoid freeze/thaw cycles.
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human placenta tissue slide using LIFR Monoclonal Antibody at dilution of 1:60.Positive staining was localized to trophoblast.)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human placenta tissue slide using LIFR Monoclonal Antibody at dilution of 1:60.Positive staining was localized to trophoblast.)
Related Product Information for anti-LIFR/CD118 antibody
LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFRantagonist (LIF05) attenuated the induced STAT3 activation and alsoresulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
leukemia inhibitory factor receptor
NCBI Official Synonym Full Names
leukemia inhibitory factor receptor alpha
NCBI Official Symbol
LIFR
NCBI Official Synonym Symbols
SWS; SJS2; STWS; CD118; LIF-R
NCBI Protein Information
leukemia inhibitory factor receptor
UniProt Protein Name
Leukemia inhibitory factor receptor
UniProt Gene Name
LIFR
UniProt Synonym Gene Names
LIF receptor; LIF-R
UniProt Entry Name
LIFR_HUMAN
Similar Products
Product Notes
The LIFR/CD118 lifr (Catalog #AAA173440) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Human LIFR/CD118 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LIFR/CD118 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the LIFR/CD118 lifr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIFR/CD118, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.