Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:FITC)
Mouse NOTCH 1 Monoclonal Antibody | anti-NOTCH 1 antibody
MOUSE ANTI MOUSE NOTCH 1:RPE
Gene Names
Notch1; N1; Mis6; Tan1; lin-12; 9930111A19Rik
Applications
Flow Cytometry, Functional Assay
Synonyms
NOTCH 1, Antibody; MOUSE ANTI MOUSE NOTCH 1:RPE; anti-NOTCH 1 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
mN1A
Form/Format
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
Sequence Length
2,516
Applicable Applications for anti-NOTCH 1 antibody
FCM/FACS (Flow Cytometry)
Reconstitution
Reconstitute with 1 ml distilled water
Perservative Stabilisers
Perservative Stabilisers
Buffer Solution
Phosphate buffered saline
Target Species
Mouse
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at 4 degree C. DO NOT FREEZE. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
Shelf Life: 12 months from date of reconstitution.
Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:FITC)
Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:FITC)
Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:Alexa Fluor 647)
Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:Alexa Fluor 647)
Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH 1:Alexa Fluor 488)
Application Data
(Staining of mouse thymocytes with Mouse anti Mouse NOTCH 1:Alexa Fluor 488)
Related Product Information for anti-NOTCH 1 antibody
Mouse anti Mouse Notch 1 antibody, clone mN1A specifically recognizes Notch 1, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Notch 1 is expressed in a range of cells including haematopoietic cells in mouse foetal liver, adult thymus and bone marrow. Notch 1 signalling plays a role in follicular differentiation, tissue homeostasis, and in both CD4+ and CD8+ cell maturation in the thymus. Studies have also implicated Notch 1 in the regulation of lymphopoeisis, myelopoiesis, and neurogenesis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
269,180 Da
NCBI Official Full Name
neurogenic locus notch homolog protein 1
NCBI Official Synonym Full Names
notch 1
NCBI Official Symbol
Notch1
NCBI Official Synonym Symbols
N1; Mis6; Tan1; lin-12; 9930111A19Rik
NCBI Protein Information
neurogenic locus notch homolog protein 1; Motch A; Notch gene homolog 1; mT14; major type A protein; p300; transmembrane receptor Notch1
UniProt Protein Name
Neurogenic locus notch homolog protein 1
UniProt Gene Name
Notch1
UniProt Synonym Gene Names
Motch; Notch 1; NEXT; NICD
UniProt Entry Name
NOTC1_MOUSE
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Product Notes
The NOTCH 1 notch1 (Catalog #AAA49500) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's NOTCH 1 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the NOTCH 1 notch1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOTCH 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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