Rat anti-Mouse Podoplanin Monoclonal Antibody
Podoplanin, Mouse, mAb LpMab-1
Reactivity
Mouse
Applications
Western Blot, Immunohistochemistry, Immunofluorescence, Functional Assay, Immunohistochemistry, Flow Cytometry, Functional Assay
Synonyms
Podoplanin, Antibody; Podoplanin, Mouse, mAb LpMab-1; Podoplanin, Mouse, clone pMab-1; Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A; anti-Podoplanin antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat IgG2a
Clone Number
LpMab-1
Form/Format
Quantities >500 ug will be send without preservative and carrier free. Quantities <500 ug will be send with preservative and carrier. exact formulation can be found on the datasheet.
Applicable Applications for anti-Podoplanin antibody
WB (Western Blot), IHC (Immunohistochemistry), IF (Immunofluorescence), FA (Functional Assay), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry)
Immunogen
Synthetic peptides, corresponding to amino acids 38-51 of mouse podoplanin (Ref. 1)
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
Related Product Information for anti-Podoplanin antibody
Monoclonal antibody pMab-1 recognizes human Podoplanin (PDPN; agrrus). Podoplanin is a small type_I transmembrane sialoglycoprotein expressed on a broad range of cell types and involved in platelet aggregation and tumor metastasis. The ca 38 kDa mouse protein was initially identified as a biomarker of lympatic endothelium, alveolar epithelium and glomerular podocytes. Expression has also been found in many tumors. However the functional role of PDPN is still poorly understood. Podoplanin consists of an extracellular domain, transmembrane domain and a cytoplasmic tail. In its extracellular domain it possesses a platelet aggregation stimulating (PLAG) domain. Podoplanin has got three PLAG domains of which PLAG3 is critical for binding with C-type lectin receptor-2 (CLEC-2). This PDPN specific receptor mediates platelet aggregation. This interaction is required to initiate and maintain separation of blood and lymphatic vessels and can be critical in process of cancer metastasis. This may lead to PDPN as possible therapeutic target. Antibody PMab-1 is produced against the platelet aggregation-stimulating domain of mouse PDPN and can be applied in western blotting, FACS and immunohistochemistry. Administration of PMab-1 in vivo reduces lymphangiogenesis in the corneal suture and ear wound healing models. PMab-1 also suppresses the infiltration of thioglycollate-induced macrophages at the site of wound healing. Furthermore, administration of PMab-1 leads to a significant suppression of the rejection reaction in the corneal transplantation model.
Product Categories/Family for anti-Podoplanin antibody
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Product Notes
The Podoplanin (Catalog #AAA77816) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Podoplanin, Mouse, mAb LpMab-1 reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Podoplanin can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IF (Immunofluorescence), FA (Functional Assay), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the Podoplanin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Podoplanin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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