Mouse anti-Human SELP / P-Selectin / CD62P Monoclonal Antibody | anti-SELP antibody

Mouse Monoclonal [clone Psel.KO.2.5] (IgG1) to Human SELP / P-Selectin / CD62P

Cat. Num. AAA51839

• Gene Names: SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified
• Synonyms: SELP / P-Selectin / CD62P, Antibody; Mouse Monoclonal [clone Psel.KO.2.5] (IgG1) to Human SELP / P-Selectin / CD62P; Anti-SELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5) IHC-plus; SELP; CD62P; CD62; GMP-140; GMRP; Granule membrane protein 140; LECAM3; P-selectin; PSEL; CD62P antigen; GMP140; Granulocyte membrane protein; GRMP; PADGEM; Human SELP; P-Selectin; anti-SELP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: Psel.KO.2.5
• Specificity: Recognizes the CD62P cell surface antigen, a 140kD glycoprotein also known as P-selectin. CD62P is expressed by activated platelets and endothelial cells, and plays an important role in adhesive processes between leucocytes and endothelial cells. To produce this mAb, P-selectin-deficient mice were immunized with a pre-B-cell line transfected with human P-selectin cDNA.
• Purity/Purification: Affinity Purified
• Form/Format: PBS, pH 7.4, 0.09% sodium azide. Sourced in TCS.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 830

• Applicable Applications for anti-SELP antibody: FCM/FACS (Flow Cytometry), IP (Immunoprecipitation), IHC (Immunohistochemistry)
• Target Species: Human
• Immunogen Description: CD62P transfected 300.19 cells.
• Immunogen Type: Cells
• Immunogen: SELP / P-Selectin / CD62P antibody was raised against cD62P transfected 300.19 cells.
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

FCM/FACS (Flow Cytometry)

(Thrombin activated human platelets stained with Mouse anti Human CD62P.)

IHC (Immunohiostchemistry)

(Anti-CD62P antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

IHC (Immunohistochemistry)

(Anti-CD62P antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Related Product Information for anti-SELP antibody

SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 157419154
• NCBI GeneID: 6403
• NCBI Accession #: NP_002996.2
• NCBI GenBank Nucleotide #: NM_003005.3
• Molecular Weight: 90,834 Da
• NCBI Official Full Name: P-selectin
• NCBI Official Synonym Full Names: selectin P (granule membrane protein 140kDa, antigen CD62)
• NCBI Official Symbol: SELP
• NCBI Official Synonym Symbols: CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
• NCBI Protein Information: P-selectin; GMP-140; granule membrane protein 140; granulocyte membrane protein; CD62 antigen-like family member P; platelet alpha-granule membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein
• UniProt Protein Name: P-selectin
• UniProt Gene Name: SELP
• UniProt Synonym Gene Names: GMRP; GRMP; GMP-140; LECAM3; PADGEM
• UniProt Entry Name: LYAM3_HUMAN